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New treatment option for Takotsubo Cardiomyopathy
Official title Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
ClinicalTrials.gov ID: NCT07491718
What this study is testing
What is Bisoprolol?
Bisoprolol is an investigational medicine, being studied as a potential treatment for takotsubo cardiomyopathy.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome. Furthermore, the investigators will be assessing the effects different cardiac medications have on these physiological mechanisms.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Males and females \>18 years of age
- Clinical presentation of takotsubo cardiomyopathy
- Have capacity to give formal consent
You likely can't join if
- Unable to tolerate or contraindication to magnetic resonance imaging
- Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) - this would be assessed by performing a blood test
- Prior history of cardiomyopathy
- Current pregnancy
- Weight greater than 250kg
- Severe asthma for study 1 (given Bisoprolol is contraindicated in this condition)
See the full eligibility criteria
- Males and females \>18 years of age
- Clinical presentation of takotsubo cardiomyopathy
- Have capacity to give formal consent
- Unable to tolerate or contraindication to magnetic resonance imaging
- Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2) - this would be assessed by performing a blood test
- Prior history of cardiomyopathy
- Current pregnancy
- Weight greater than 250kg
- Severe asthma for study 1 (given Bisoprolol is contraindicated in this condition)
- Type 1 diabetes mellitus for study 2 (given Dapaglifozin is contraindicated in this population)
- Significant hypotension (given the medications prescribed as part of the study can also cause hypotension as a side effect)
- Significant bradycardia for study 1 (given Bisoprolol can exacerbate any pre-existing significant bradycardia)
- Prescribed Digoxin (this medication interacts with the Manganese)
- Unable to give formal consent
The study team makes the final eligibility decision.
Where it's taking place
- Edinburgh, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Edinburgh, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.