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New treatment option for Hemodynamic (MAP) Stability
Official title Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section
ClinicalTrials.gov ID: NCT07480889
What this study is testing
What is Epinephrine (Adrenaline) bolus then infusion?
Epinephrine (Adrenaline) bolus then infusion is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for hemodynamic (map) stability.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- In North America, norepinephrine, ephedrine, and epinephrine have been recommended as first-choice vasopressors for the treatment of spinal hypotension during cesarean delivery. However, in international consensus guidelines, epinephrine was recommended for circulatory collapse only.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35, women only
You may be able to join if
- Age: 18 to 35 years.
- American Society of Anesthesiologists (ASA) physical status II.
- Undergoing Elective Lower Segment Cesarean Section under Spinal Anesthesia.
You likely can't join if
- Uncontrolled cardiac morbidities as reduction of ejection fraction\< 60%, History (within 3months) of myocardial infarction, cerebrovascular...
- Poorly controlled Hypertensive disorders of pregnancy
- Peripartum bleeding
- Multiple pregnancies (e.g., twin gestations)
- Coagulation disorders defined as platelet count \ 1.4, or known inherited clotting factor deficiency.
- Baseline systolic blood pressure (SBP) \ 130 mmHg
See the full eligibility criteria
- Age: 18 to 35 years.
- American Society of Anesthesiologists (ASA) physical status II.
- Undergoing Elective Lower Segment Cesarean Section under Spinal Anesthesia.
- Uncontrolled cardiac morbidities as reduction of ejection fraction\< 60%, History (within 3months) of myocardial infarction, cerebrovascular accident, transient ischemic attacks or coronary artery disease/stents
- Poorly controlled Hypertensive disorders of pregnancy
- Peripartum bleeding
- Multiple pregnancies (e.g., twin gestations)
- Coagulation disorders defined as platelet count \ 1.4, or known inherited clotting factor deficiency.
- Baseline systolic blood pressure (SBP) \ 130 mmHg
- Refusal of patients.
The study team makes the final eligibility decision.
Where it's taking place
- Cairo, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 35 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Cairo, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.