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New treatment option for Osteogenesis Imperfecta, Type I
Official title An Interventional Study to Evaluate the Impact of Blood Flow Restriction Training on Muscle, Bone, and Quality of Life in Adults With Osteogenesis Imperfecta Type I
ClinicalTrials.gov ID: NCT07478224
What this study is testing
- What it's testing
- Background: Due to fear of injury and risk of fractures, many people with osteogenesis imperfecta (OI) avoid vigorous exercise that is likely to improve muscle and bone weakness common in this disorder. Low-intensity muscle strength training with blood flow restriction (BFR-LI) via an inflatable cuff leads to similar improvements in muscle size and strength to conventional high-intensity strength training but has not been applied in OI.Objectives: To evaluate the effect of BFR-LI on muscle and bone health and quality of life in adults with OI type I.Methods: For this randomized controlled trial, 40 adults (18-65y) with OI type I will be recruited.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Osteogenesis imperfecta type I, aged between 18 and 65 years old
You likely can't join if
- Lower limbs: Edema; Recent surgery; Acute fractures
- Pregnancy/\<6 months postpartum
- Deep vein thrombosis (now or history of)
- Cardiovascular, respiratory, or neuromuscular diseases
- Recent cardiovascular events/untreated hypertension
- Diseases affecting vascular function (e.g., diabetes)
See the full eligibility criteria
- Osteogenesis imperfecta type I, aged between 18 and 65 years old
- Lower limbs: Edema; Recent surgery; Acute fractures
- Pregnancy/\<6 months postpartum
- Deep vein thrombosis (now or history of)
- Cardiovascular, respiratory, or neuromuscular diseases
- Recent cardiovascular events/untreated hypertension
- Diseases affecting vascular function (e.g., diabetes)
- Vigorous strength training in year before study
- Other contraindications to perform exercise
The study team makes the final eligibility decision.
Where it's taking place
- Ghent, Belgium
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ghent, Belgium. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.