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New treatment option for Periodontitis
Official title "Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"
ClinicalTrials.gov ID: NCT07459049
What this study is testing
What is Non surgical root surface debridement in one stage with receiving Ibuprofen?
Non surgical root surface debridement in one stage with receiving Ibuprofen is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for periodontitis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy. The main question it aims to answer is: "Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?"
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- systemically healthy patients.
- having a minimum of 20 teeth.
- Generalized unstable periodontitis.
- Pocket depth [≥ 4 mm].
- All included participants should be adults aged more than 18 years .
You likely can't join if
- Allergy or hypersensitivity to Ibuprofen or other NSAIDs.
- current systemic anti-inflammatory or antibiotic therapy (\<3 months).
- peptic ulcer disease.
- recent periodontal therapy (\<3 months).
- Asthma.
- Renal impairment .
See the full eligibility criteria
- systemically healthy patients.
- having a minimum of 20 teeth.
- Generalized unstable periodontitis.
- Pocket depth [≥ 4 mm].
- All included participants should be adults aged more than 18 years .
- smokers and non smokers
- Allergy or hypersensitivity to Ibuprofen or other NSAIDs.
- current systemic anti-inflammatory or antibiotic therapy (\<3 months).
- peptic ulcer disease.
- recent periodontal therapy (\<3 months).
- Asthma.
- Renal impairment .
- Hepatic impairment.
- Severe cardiac disease (heart failure, hypertension (.
- Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .
- Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.
- pregnant or lactating females.
- those being unable to provide written informed consent.
The study team makes the final eligibility decision.
Where it's taking place
- Baghdad, Iraq
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baghdad, Iraq. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.