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New treatment option for Muscle Mass and Strength
Official title Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment
ClinicalTrials.gov ID: NCT07457437
What this study is testing
- What it's testing
- This study aims to investigate the effect that a structured, progressive resistance exercise program may have on maintaining the muscle mass and physical function of overweight/ obese females whilst they experience a tirzepatide (GLP-1/GIP receptor agonist) induced weight loss. Overweight and obese females aged 25-50 will be recruited for the study, they will require a BMI of \>30 or \>27 with one obesity related comorbidity (excluding diabetes).
- Time commitment: about 72 weeks
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 to 50, women only. Healthy volunteers may be eligible.
You may be able to join if
- 25-50 years old
- BMI ≥27 kg/m2 with one obesity related co-morbidity or a BMI between ≥30 and 35 kg/m2
- Female
You likely can't join if
- Previous GLP-1RA use
- Diabetes (Type 1 and 2)
- Contraindicative health condition to GLP-1/GIP
- Fail clinically administered health screening form for tirzepatide prescription
- Pregnant or wanting to become pregnant in the next 6 months
- Has or has previously had an eating disorder
See the full eligibility criteria
- 25-50 years old
- BMI ≥27 kg/m2 with one obesity related co-morbidity or a BMI between ≥30 and 35 kg/m2
- Female
- Previous GLP-1RA use
- Diabetes (Type 1 and 2)
- Contraindicative health condition to GLP-1/GIP
- Fail clinically administered health screening form for tirzepatide prescription
- Pregnant or wanting to become pregnant in the next 6 months
- Has or has previously had an eating disorder
- Inability to perform exercise program and exercise tests
- Advised not to exercise by their general practitioner or medical professional
- Current or recent injury within the last 6 months that may affect the ability to carry out resistance exercise
- Has consistently resistance trained previously (\>10 sessions per year)
- Currently taking medication or supplements that have been shown to impact muscle function and muscle mass in the last 6 months
- Current or recent, ≤6 months, smoker
- Currently on HRT
The study team makes the final eligibility decision.
Where it's taking place
- Exeter, Devon, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 72 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling female, 25 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Exeter, Devon, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.