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New treatment option for Persistent Apical Periodontitis
Official title Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
ClinicalTrials.gov ID: NCT07453576
What this study is testing
What is Sodium Hypochlorite 1% Irrigation?
Sodium Hypochlorite 1% Irrigation is an investigational medicine, being studied as a potential treatment for persistent apical periodontitis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Patients aged between 18 and 65 years.
- Systemically healthy individuals (ASA I or II)
- Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
- Patients who provide written informed consent.
You likely can't join if
- Patients with systemic diseases that may affect pain perception or inflammatory response.
- Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment.
- Pregnant or lactating women.
- Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth.
- Teeth with open apices or immature root development.
- Presence of acute apical abscess with swelling or sinus tract.
See the full eligibility criteria
- Patients aged between 18 and 65 years.
- Systemically healthy individuals (ASA I or II)
- Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
- Patients who provide written informed consent.
- Patients with systemic diseases that may affect pain perception or inflammatory response.
- Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment.
- Pregnant or lactating women.
- Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth.
- Teeth with open apices or immature root development.
- Presence of acute apical abscess with swelling or sinus tract.
- Patients with known allergy to sodium hypochlorite.
- Inability to achieve adequate isolation with rubber dam.
- Patients unable to attend follow-up or complete pain assessment forms.
The study team makes the final eligibility decision.
Where it's taking place
- Erzurum, Erzurum, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Erzurum, Erzurum, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.