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New treatment option for Stress Response
Official title Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults
ClinicalTrials.gov ID: NCT07453537
What this study is testing
- What it's testing
- This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1).
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 55. Healthy volunteers may be eligible.
You may be able to join if
- At least 110 pounds
- Between 30 and 55 years
- BMI between 18.9 and 29.9 kg/m²
- A minimum education level of high school or above
You likely can't join if
- Heavy caffeine users (consuming more than 300 mg/day or more than two cups of coffee per day)
- Alcohol consumption exceeding three drinks per week
- A smoking history of 10 years or more, or current use of cannabis products
- Uncontrolled hypertension
- Clinically diagnosed illnesses such as diabetes, cardiovascular disease, neurological disorders, or mental health conditions
- Participants currently taking prescribed anti-inflammatory medications, antibiotics, or antidepressants that may affect study outcomes, particularly...
See the full eligibility criteria
- At least 110 pounds
- Between 30 and 55 years
- BMI between 18.9 and 29.9 kg/m²
- A minimum education level of high school or above
- Heavy caffeine users (consuming more than 300 mg/day or more than two cups of coffee per day)
- Alcohol consumption exceeding three drinks per week
- A smoking history of 10 years or more, or current use of cannabis products
- Uncontrolled hypertension
- Clinically diagnosed illnesses such as diabetes, cardiovascular disease, neurological disorders, or mental health conditions
- Participants currently taking prescribed anti-inflammatory medications, antibiotics, or antidepressants that may affect study outcomes, particularly those related to blood and fecal sample analysis
- Individuals who regularly take vitamin or mineral supplements and are unwilling to discontinue them for the duration of the study will not qualify.
- Participants must be willing to maintain their current daily routine and lifestyle, undergo body weight and height measurements, and notify study coordinators of any illnesses or significant adverse life events during...
- Those with specific dietary restrictions that prevent them from consuming the standardized breakfast sandwich required in the study protocol
- Participants must successfully complete the on-site multitasking task as a screening measure prior to signing consent.
- Beck's Depression Inventory score of 21 or higher
- Beck's Anxiety Inventory score of 21 or higher
- A history of severe suicidal tendencies, or seasonal depression
- Pregnancy and breastfeeding (Female participants must complete four pregnancy tests throughout the study and track their menstrual cycle. Those unwilling to comply with these requirements will not be eligible.)
- Potential participants must not have taken any anti-inflammatory medications, antibiotics, or antidepressants within the past three months prior to the start of the study
- Individuals who were previously enrolled in IRB#202300950 will be excluded due to the learning effect of cognitive tests, ensuring accurate data collection for this study
The study team makes the final eligibility decision.
Where it's taking place
- Gainesville, Florida, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 55 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Gainesville, Florida, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.