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New treatment option for Chronic Respiratory Failure
Official title Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia
ClinicalTrials.gov ID: NCT07451977
What this study is testing
- What it's testing
- The aim of this multicenter crossover trial is to describe the effect of adding a therapeutic dose of exertional oxygen therapy, in terms of exercise performance, gas exchange, heart rate, symptoms perception and subjective easiness of performance, in a cohort of subjects hospitalized in specialized pulmonary rehabilitation centers with a diagnosis of chronic respiratory failure and/or exertional hypoxemia due to chronic obstructive pulmonary disease or interstitial lung disease. Researchers will compare the walking performance during 6-minute walk test performed with the liters of oxygen administered as prescribed at rest (for patients with chronic respiratory failure) or in room air (for patients with exertional hypoxemia only), to the performance during a 6-minute walk test performed with the double the flow rate prescribed at rest, or with 2 L/min for patients with exertional hypoxemia only.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults aged 18 years or older
- Diagnosis of chronic respiratory disease admitted for pulmonary rehabilitation
- One of the following conditions at discharge:
- Chronic obstructive pulmonary disease with exertional hypoxemia
- Chronic obstructive pulmonary disease with chronic respiratory failure requiring long-term oxygen therapy
You likely can't join if
- Lung diseases other than chronic obstructive pulmonary disease or interstitial lung disease
- Resting oxygen flow requirement greater than 4 liters per minute
- Orthopedic, neurological, or cognitive conditions that may limit walking performance
- Recent cardiovascular or cerebrovascular events within the previous 3 months
See the full eligibility criteria
- Adults aged 18 years or older
- Diagnosis of chronic respiratory disease admitted for pulmonary rehabilitation
- One of the following conditions at discharge:
- Chronic obstructive pulmonary disease with exertional hypoxemia
- Chronic obstructive pulmonary disease with chronic respiratory failure requiring long-term oxygen therapy
- Interstitial lung disease with chronic respiratory failure requiring long-term oxygen therapy
- Clinically stable condition for at least one month
- Optimized medical therapy during hospitalization
- Ability to perform the 6-minute walk test
- Signed informed consent
- Lung diseases other than chronic obstructive pulmonary disease or interstitial lung disease
- Resting oxygen flow requirement greater than 4 liters per minute
- Orthopedic, neurological, or cognitive conditions that may limit walking performance
- Recent cardiovascular or cerebrovascular events within the previous 3 months
The study team makes the final eligibility decision.
Where it's taking place
- Lumezzane, Brescia, Italy
- Veruno, Novara, Italy
- Montescano, Pavia, Italy
- Bari, Italy
- Pavia, Italy
- Taranto, Italy
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lumezzane, Brescia, Italy; Veruno, Novara, Italy; Montescano, Pavia, Italy; Bari, Italy; Pavia, Italy; Taranto, Italy. Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.