BridgeMD
New treatment option for Ageing
Official title PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
ClinicalTrials.gov ID: NCT07451496
What this study is testing
- What it's testing
- As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80. Healthy volunteers may be eligible.
You may be able to join if
- Age 50-80 years (both male and female)
- Relatively healthy and in stable health condition
- Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
- VO₂peak below the 75th percentile for age- and sex-specific norms
- Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery
You likely can't join if
- Significant change in medication in the past 3 months
- History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
- More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
- Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
- Participation in another treatment clinical trial
- Current use of any study-related supplement unless willing to stop
See the full eligibility criteria
- Age 50-80 years (both male and female)
- Relatively healthy and in stable health condition
- Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
- VO₂peak below the 75th percentile for age- and sex-specific norms
- Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery
- Willing and able to comply with exercise and supplementation protocols
- English-literate (can read and understand English)
- Provides written informed consent
- Deemed to have mental capacity, as assessed by the Principal Investigator
- Are able to attend all research visits for screening and research data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore
- Significant change in medication in the past 3 months
- History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
- More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
- Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
- Participation in another treatment clinical trial
- Current use of any study-related supplement unless willing to stop
- Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance
- Pregnant or planning pregnancy during the study period
- Any conditions deemed by PI that jeopardize the safety or study compliance
The study team makes the final eligibility decision.
Where it's taking place
- Singapore, Singapore, Singapore
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Singapore, Singapore, Singapore. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.