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New treatment option for Corneal Scarring Fibrosis
Official title Losartan for Corneal Fibrosis
ClinicalTrials.gov ID: NCT07449000
What this study is testing
What is Topical losartan?
Topical losartan is an investigational medicine, given as an once-daily treatment applied to the skin, being studied as a potential treatment for corneal scarring fibrosis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry, corneal aberrations and corneal scarring severity in adult patients with corneal scars of different etiologies. Participants will be randomly assigned to receive either topical losartan 0.8 mg/mL or placebo eyedrops 6 times per day for six months.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults aged 18 years or older
- Presence of corneal scar with a duration of at least 1 month
- Corneal scars of any etiology
- Corneal scars with or without corneal neovascularization
- Stable corneal scar without epithelial defect
You likely can't join if
- Refusal or inability to provide written informed consent
- Presence of corneal epithelial defect or friable epithelium
- Age under 18 years
- Pregnancy
- Known allergy or hypersensitivity to losartan
See the full eligibility criteria
- Adults aged 18 years or older
- Presence of corneal scar with a duration of at least 1 month
- Corneal scars of any etiology
- Corneal scars with or without corneal neovascularization
- Stable corneal scar without epithelial defect
- No active treatment for the underlying condition for at least 1 month
- Refusal or inability to provide written informed consent
- Presence of corneal epithelial defect or friable epithelium
- Age under 18 years
- Pregnancy
- Known allergy or hypersensitivity to losartan
The study team makes the final eligibility decision.
Where it's taking place
- Monterrey, Nueo Leon, Mexico
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Monterrey, Nueo Leon, Mexico. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.