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Official title High Phenolic Olive Oil for Enhancing Metabolic Health: a Randomized-controlled Trial in Patients With cEntral Obesity (HOPE)
ClinicalTrials.gov ID: NCT07445503
What this study is testing
- What it's testing
- Olive oil is a fundamental component of the Mediterranean diet and a major source of monounsaturated fatty acids with well-established cardioprotective properties. When rich in phenolic compounds-such as hydroxytyrosol, tyrosol, oleuropein, oleocanthal, oleacein, and ligstroside aglycone-it is considered a functional food with antioxidant, anti-inflammatory, cardioprotective, chemoprotective, and neuroprotective effects.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Adult men and women 18-80 years of age,
- Overweight/obesity (body mass index \> 25 or waist circumference \>94 cm for males and \>80 cm for females), and
- The presence of at least one of the following metabolic abnormality: (1) triglyceride level ≥150 mg/dL or HDL cholesterol ≤40 mg/dL in men and ≤50...
- Provided signed informed consent for participation.
You likely can't join if
- Concomitant acute or chronic disease (e.g., infection, cancer, chronic heart failure, kidney disease, autoimmune diseases like rheumatoid arthritis...
- Untreated diabetes,
- Women at pregnancy or lactation,
- Individuals with psychiatric or mental disorder,
- Any use of antioxidant-phytochemical rich supplement, anti-, pre- or probiotics pre-intervention,
- Drug and/or alcohol abuse,
See the full eligibility criteria
- Adult men and women 18-80 years of age,
- Overweight/obesity (body mass index \> 25 or waist circumference \>94 cm for males and \>80 cm for females), and
- The presence of at least one of the following metabolic abnormality: (1) triglyceride level ≥150 mg/dL or HDL cholesterol ≤40 mg/dL in men and ≤50 mg/dL in women; (2) increased blood pressure ≥ 130/85 mm Hg; (3)...
- Provided signed informed consent for participation.
- Concomitant acute or chronic disease (e.g., infection, cancer, chronic heart failure, kidney disease, autoimmune diseases like rheumatoid arthritis, inflammatory bowel diseases, Hashimoto),
- Untreated diabetes,
- Women at pregnancy or lactation,
- Individuals with psychiatric or mental disorder,
- Any use of antioxidant-phytochemical rich supplement, anti-, pre- or probiotics pre-intervention,
- Drug and/or alcohol abuse,
- Those who did not consent or were unable to provide consent.
The study team makes the final eligibility decision.
Where it's taking place
- Kalamata, Greece
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kalamata, Greece. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.