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New treatment option for Periodontitis, Adult
Official title Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
ClinicalTrials.gov ID: NCT07443410
What this study is testing
- What it's testing
- Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response. Standard non-surgical periodontal therapy (NSPT) is primarily mechanical and, in selected cases, may be accompanied by antiseptics or systemic antibiotics.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age ≥ 18 years
- Stage III or IV periodontitis (localized or generalized)
- Ability to provide informed consent
- Written informed consent including data protection consent
You likely can't join if
- Pregnancy or breastfeeding
- Conditions/medications likely to substantially confound the oral microbiome or periodontal healing (e.g., uncontrolled diabetes mellitus, systemic...
- Antibiotic use within the last 3 months
- Use of oral pre-/probiotic supplements within the last 3 months
- Recent subgingival instrumentation within the last 6 months
- Need for obligatory adjunctive systemic antibiotic prophylaxis/therapy for NSPT
See the full eligibility criteria
- Age ≥ 18 years
- Stage III or IV periodontitis (localized or generalized)
- Ability to provide informed consent
- Written informed consent including data protection consent
- Pregnancy or breastfeeding
- Conditions/medications likely to substantially confound the oral microbiome or periodontal healing (e.g., uncontrolled diabetes mellitus, systemic immunosuppression, chronic steroid use)
- Antibiotic use within the last 3 months
- Use of oral pre-/probiotic supplements within the last 3 months
- Recent subgingival instrumentation within the last 6 months
- Need for obligatory adjunctive systemic antibiotic prophylaxis/therapy for NSPT
- Severe active systemic infection or other conditions judged by investigators to pose undue risk
- Regular use of antiseptic mouthrinses during the study period (unless medically required)
- Strict diets likely to substantially alter baseline microbiome trajectories (e.g., ketogenic, strict vegan) per protocol definition
- Chronic bowel diseases (for systemic confounding considerations)
The study team makes the final eligibility decision.
Where it's taking place
- Heidelberg, Baden-Wurttemberg, Germany
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Heidelberg, Baden-Wurttemberg, Germany. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.