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New treatment option for Chronic Stroke Patient
Official title Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)
ClinicalTrials.gov ID: NCT07439367
What this study is testing
- What it's testing
- Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- For Stroke Participants:
- Age ≥ 18 years
- First-ever ischemic or hemorrhagic stroke
- Time since stroke ≥ 6 months
- Unilateral upper limb hemiparesis
You likely can't join if
- For Stroke Participants:
- Second stroke occurring during the study period
- Botulinum toxin injection within 3 months prior to study start
- History of one or more epileptic seizures
- Metallic object near the stimulation site
- Implanted electronic or metallic devices (e.g., pacemaker, neurostimulator) incompatible with TMS
See the full eligibility criteria
- For Stroke Participants:
- Age ≥ 18 years
- First-ever ischemic or hemorrhagic stroke
- Time since stroke ≥ 6 months
- Unilateral upper limb hemiparesis
- Fugl-Meyer Assessment Upper Extremity (FMA-UE) score between 29 and 57
- Modified Ashworth Scale score \< 2 at elbow, wrist, or finger flexors
- Manual muscle testing ≥ 3/5 in proximal upper limb muscles (deltoid, biceps, triceps, wrist pronators/supinators)
- Ability to understand and follow study procedures
- Provided written informed consent For Healthy Participants:
- Age ≥ 18 years
- No history of neurological disease
- Ability to understand and follow study procedures
- Provided written informed consent
- For Stroke Participants:
- Second stroke occurring during the study period
- Botulinum toxin injection within 3 months prior to study start
- History of one or more epileptic seizures
- Metallic object near the stimulation site
- Implanted electronic or metallic devices (e.g., pacemaker, neurostimulator) incompatible with TMS
- Severe comorbid conditions affecting the upper limb (traumatic, rheumatologic, osteoarticular, or neurodegenerative disorders)
- Pregnancy
- Delirium or impaired vigilance
- Inability to participate in one-hour treatment sessions
- Inability to comply with study procedures (e.g., language barrier, psychological disorder, dementia)
- Current or past substance abuse, including excessive alcohol consumption
- Participation in another treatment clinical trial within 30 days prior to enrollment For Healthy Participants:
- Severe musculoskeletal or neurological condition affecting the non-dominant upper limb
- Pregnancy
- Delirium or impaired vigilance
- Inability to participate in one-hour treatment sessions
- Inability to comply with study procedures
- Current or past substance abuse, including excessive alcohol consumption
- Participation in another treatment clinical trial within 30 days prior to enrollment
The study team makes the final eligibility decision.
Where it's taking place
- Carouge, Canton of Geneva, Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Carouge, Canton of Geneva, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.