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New treatment option for Mechanical Ventilation
Official title Impact of PEEP on Respiratory Effort During Assisted Ventilation
ClinicalTrials.gov ID: NCT07437846
What this study is testing
- What it's testing
- Assisted mechanical ventilation is widely used to preserve diaphragmatic activity and improve lung aeration in patients with acute respiratory failure. However, during assisted ventilation, excessive inspiratory effort may develop and contribute to lung injury, diaphragmatic overload, and patient self-inflicted lung injury.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years.
- ICU patients receiving invasive mechanical ventilation (endotracheal tube or tracheostomy).
- Ventilated in an assisted mode with spontaneous breathing
- Clinically stable to undergo protocolized PEEP changes.
- Sedation level compatible with spontaneous breathing and ventilator triggering
You likely can't join if
- Contraindication to esophageal balloon placement (if applicable).
- Significant hemodynamic instability or unstable vasopressor requirements.
- Unstable arrhythmia or active myocardial ischemia.
- Undrained pneumothorax or major air leak.
- Controlled ventilation without effective spontaneous effort (apnea, neuromuscular blockade, deep sedation).
- Pregnancy
See the full eligibility criteria
- Age ≥18 years.
- ICU patients receiving invasive mechanical ventilation (endotracheal tube or tracheostomy).
- Ventilated in an assisted mode with spontaneous breathing
- Clinically stable to undergo protocolized PEEP changes.
- Sedation level compatible with spontaneous breathing and ventilator triggering
- Informed consent from the patient or legally authorized representative.
- Contraindication to esophageal balloon placement (if applicable).
- Significant hemodynamic instability or unstable vasopressor requirements.
- Unstable arrhythmia or active myocardial ischemia.
- Undrained pneumothorax or major air leak.
- Controlled ventilation without effective spontaneous effort (apnea, neuromuscular blockade, deep sedation).
- Pregnancy
- Acute or chronic neurological conditions that may impair respiratory drive or interfere with the regulation of spontaneous breathing.
The study team makes the final eligibility decision.
Where it's taking place
- Santiago, Santiago Metropolitan, Chile
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Santiago, Santiago Metropolitan, Chile. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.