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Compares treatment options for Hip Fractures
Official title One Versus Two Doses of Tranexamic Acid in Surgically Treated Extracapsular Hip Fractures
ClinicalTrials.gov ID: NCT07432737
What this study is testing
What is Tranexamic acid?
Tranexamic acid is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for hip fractures.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn whether giving one dose or two doses of tranexamic acid can safely lower blood loss in older adults having surgery for certain hip fractures. The study includes adults aged 65 years or older who need surgery for pertrochanteric or subtrochanteric hip fractures.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- Written informed consent obtained
- Patients aged 65 years or older
- Patients with pertrochanteric femoral fracture (AO/OTA classification: 31A1.2, 31A1.3, 31A2, 31A3) or subtrochanteric femoral fracture (AO/OTA...
- Surgical treatment performed within 48 hours of hospital admission
You likely can't join if
- Age younger than 65 years
- Known allergy or hypersensitivity to tranexamic acid
- Active thromboembolic event (deep vein thrombosis, arterial thrombosis, pulmonary embolism) or history of vascular event within the past year...
- Impaired renal function defined as serum creatinine \>120 µmol/L in the last preoperative laboratory test
- History of malignant disease
- History of seizure disorder or chronic anticonvulsant therapy
See the full eligibility criteria
- Written informed consent obtained
- Patients aged 65 years or older
- Patients with pertrochanteric femoral fracture (AO/OTA classification: 31A1.2, 31A1.3, 31A2, 31A3) or subtrochanteric femoral fracture (AO/OTA classification: 32; fractures from the level of the lesser trochanter to 5...
- Surgical treatment performed within 48 hours of hospital admission
- Age younger than 65 years
- Known allergy or hypersensitivity to tranexamic acid
- Active thromboembolic event (deep vein thrombosis, arterial thrombosis, pulmonary embolism) or history of vascular event within the past year (myocardial infarction, coronary or peripheral vascular stenting...
- Impaired renal function defined as serum creatinine \>120 µmol/L in the last preoperative laboratory test
- History of malignant disease
- History of seizure disorder or chronic anticonvulsant therapy
- Polytrauma or multiple trauma
- More than one fracture
- Previous fracture of the same hip
- Preoperative hemoglobin level \<8 g/dL (last laboratory test before surgery)
- Thrombocytopenia or other coagulation disorders
- Treatment with vitamin K antagonists with INR \>1.5
- Treatment with low-molecular-weight heparins without appropriate preoperative discontinuation according to clinical protocol (usually ≥24 hours for prophylactic doses and ≥24-36 hours for therapeutic doses)
- Treatment with direct oral anticoagulants without appropriate preoperative discontinuation (usually 24-48 hours, depending on renal function and bleeding risk)
- Treatment with P2Y12 inhibitors (e.g., ticagrelor, clopidogrel, prasugrel) when, according to anesthesiologist assessment, surgery cannot be safely performed within 48 hours
The study team makes the final eligibility decision.
Where it's taking place
- Skopje, North Macedonia
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Skopje, North Macedonia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.