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New treatment option for Glaucoma
Official title Optic Nerve Head Strain in Non-glaucoma Subjects
ClinicalTrials.gov ID: NCT07425535
What this study is testing
What is Latanoprost (0.005%)?
Latanoprost (0.005%) is an investigational medicine, given as an once-daily, being studied as a potential treatment for glaucoma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 90. Healthy volunteers may be eligible.
You may be able to join if
- Adults who have no history of OAG
- Have an ocular examination by a glaucoma specialist with no indications of OAG
- Have normal optical coherence tomography findings in the retinal nerve fiber layer.
- Over age 30 will be included from
- Both sexes
You likely can't join if
- , both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual...
- in whom sitting in an upright position is impossible due to physical disability
- with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
- in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
- who cannot perform home tonometry accurately at certification
- who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
See the full eligibility criteria
- Adults who have no history of OAG
- Have an ocular examination by a glaucoma specialist with no indications of OAG
- Have normal optical coherence tomography findings in the retinal nerve fiber layer.
- Over age 30 will be included from
- Both sexes
- All ethnic groups.
- Optic neuropathy.
- Both suspects and those with glaucoma damage will be included.
- When both eyes meet inclusion and
- , both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual. Exclusion Criteria:
- in whom sitting in an upright position is impossible due to physical disability
- with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
- in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
- who cannot perform home tonometry accurately at certification
- who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
- with any form of glaucoma
- with high myopia defined as refractive error \> -8
- with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
- inability to understand English or with a language or hearing impairment
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.