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New treatment option for Mediastinal Lymphadenopathy
Official title Comparison of Two Needle Agitation Strategies in Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) for Diagnostic Yield
ClinicalTrials.gov ID: NCT07424807
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn whether the number of needle agitations during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) affects diagnostic yield in patients with enlarged mediastinal lymph nodes. The study will also evaluate tissue sample quality and the safety of different needle agitation strategies.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years
- Presence of enlarged mediastinal or hilar lymph nodes requiring diagnostic evaluation on chest computed tomography (CT), defined as short-axis...
- Clinical indication for EBUS-TBNA
- Ability to provide written informed consent
You likely can't join if
- Uncorrected coagulation disorders (platelet count \ 1.5; or prothrombin time \< 50% of control)
- Acute myocardial infarction within the preceding 4 weeks or ongoing unstable angina
- Significant upper airway obstruction (benign or malignant) with ≥ 50% reduction in tracheal lumen diameter
- Hemodynamic instability (e.g., persistent hypotension, significant arrhythmia, or need for vasopressors)
- Respiratory failure refractory to oxygen therapy, defined as sustained Peripheral oxygen saturation (SpO₂) ≤ 90% despite supplemental oxygen
- Intractable cough precluding bronchoscopy
See the full eligibility criteria
- Age ≥ 18 years
- Presence of enlarged mediastinal or hilar lymph nodes requiring diagnostic evaluation on chest computed tomography (CT), defined as short-axis diameter ≥ 10 mm measured on axial images
- Clinical indication for EBUS-TBNA
- Ability to provide written informed consent
- Uncorrected coagulation disorders (platelet count \ 1.5; or prothrombin time \< 50% of control)
- Acute myocardial infarction within the preceding 4 weeks or ongoing unstable angina
- Significant upper airway obstruction (benign or malignant) with ≥ 50% reduction in tracheal lumen diameter
- Hemodynamic instability (e.g., persistent hypotension, significant arrhythmia, or need for vasopressors)
- Respiratory failure refractory to oxygen therapy, defined as sustained Peripheral oxygen saturation (SpO₂) ≤ 90% despite supplemental oxygen
- Intractable cough precluding bronchoscopy
- History of severe allergy to local anesthetics or sedative agents used during the procedure
- Refusal or inability to provide informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Ho Chi Minh City, Ho Chi Minh, Vietnam
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ho Chi Minh City, Ho Chi Minh, Vietnam. Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.