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New treatment option for Bronchopulmonary Dysplasia (BPD)
Official title Continued Pressure for Alveolar Protection (CPAP Trial)
ClinicalTrials.gov ID: NCT07417111
What this study is testing
- What it's testing
- The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages up to 31
You may be able to join if
- Gestational age \<29 weeks at birth
- PMA \<32 weeks at study entry
- On treatment with CPAP without a rate in FiO2 \<0.25 and PEEP of 4-5 cmH2O
- Meet stability criteria:
- If previously intubated must be extubated ≥ 72 hours
You likely can't join if
- Major malformation
- Neuromuscular condition that affects respiration
- Terminal illness
- Decision to withhold or limit support
- Too sick to participate in opinion of Attending physician
- Clinical shock, sepsis
See the full eligibility criteria
- Gestational age \<29 weeks at birth
- PMA \<32 weeks at study entry
- On treatment with CPAP without a rate in FiO2 \<0.25 and PEEP of 4-5 cmH2O
- Meet stability criteria:
- If previously intubated must be extubated ≥ 72 hours
- \<3 self-resolving apneas (≤ 20 s) and/or bradycardia (\<100 bpm) in any hour over previous 6 hours
- No episodes of apnea or bradycardia requiring intervention (oxygen/stimulation/bag and mask) for 24 hours
- Parents/legal guardians consent for enrollment
- Major malformation
- Neuromuscular condition that affects respiration
- Terminal illness
- Decision to withhold or limit support
- Too sick to participate in opinion of Attending physician
- Clinical shock, sepsis
- Planned surgery during study period
The study team makes the final eligibility decision.
Where it's taking place
- Birmingham, Alabama, United States
- Palo Alto, California, United States
- San Diego, California, United States
- Atlanta, Georgia, United States
- Chicago, Illinois, United States
- Iowa City, Iowa, United States
- Jackson, Mississippi, United States
- Albuquerque, New Mexico, United States
- Durham, North Carolina, United States
- Cincinnati, Ohio, United States
- Cleveland, Ohio, United States
- Philadelphia, Pennsylvania, United States
- Dallas, Texas, United States
- Houston, Texas, United States
- Salt Lake City, Utah, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, up to 31 weeks. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Birmingham, Alabama, United States; Palo Alto, California, United States; San Diego, California, United States; Atlanta, Georgia, United States; Chicago, Illinois, United States; Iowa City, Iowa, United States and 9 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.