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New treatment option for Aging
Official title The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
ClinicalTrials.gov ID: NCT07415707
What this study is testing
- What it's testing
- The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 to 84
You may be able to join if
- Between 65 and 84 years of age
- English speaking
- Able to provide valid informed consent, understand requirement and risk/benefits of the study and comply with study protocol
- Heavy drinker defined as \>14 alcoholic drinks/week for men and \>7 drinks/week for women
- Interested in reducing their alcohol consumption
You likely can't join if
- BMI ≥ 35
- Fasting Glucose \> 125 mg/dL
- Current or previously diagnosed with Type 1 or 2 Diabetes
- Requires the use of insulin and/or other glucose lowering agents
- Unable to fast for 12 hours
- Past serious alcohol withdrawal symptoms
See the full eligibility criteria
- Between 65 and 84 years of age
- English speaking
- Able to provide valid informed consent, understand requirement and risk/benefits of the study and comply with study protocol
- Heavy drinker defined as \>14 alcoholic drinks/week for men and \>7 drinks/week for women
- Interested in reducing their alcohol consumption
- BMI ≥ 35
- Fasting Glucose \> 125 mg/dL
- Current or previously diagnosed with Type 1 or 2 Diabetes
- Requires the use of insulin and/or other glucose lowering agents
- Unable to fast for 12 hours
- Past serious alcohol withdrawal symptoms
- MRI Contraindications (e.g., certain devices and implants, claustrophobic)
- Diagnosed with a neurodegenerative disease (e.g., Alzheimer's Disease)
- Diagnosed with a psychotic disorder
- Current substance dependence diagnosis (except for mild or moderate alcohol)
- Consumption of over 300 drinks in the past 30 days
- Current probiotic use or recent probiotic use within the past 30 days
- Current antibiotic use or recent antibiotic use within the past 30 days
- In active cancer treatment and/or have advanced cancer
- Taking daily steroids and/or immunosuppressants
- Lifetime organ or bone marrow transplant; primary immunodeficiency (e.g., DiGeorge syndrome or Wiskott-Aldrich syndrome) or transplant recipient or prescribed immunosuppressant medications
- PI's discretion
The study team makes the final eligibility decision.
Where it's taking place
- Miami, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years to 84 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Miami, Florida, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.