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New treatment option for Periodontitis
Official title MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery
ClinicalTrials.gov ID: NCT07414498
What this study is testing
- What it's testing
- This clinical study investigates how the subgingival microbiome changes after three different periodontal and peri-implant surgical procedures: (1) resective periodontal surgery, (2) regenerative periodontal surgery, and (3) peri-implantitis surgery. The aim is to characterize microbial shifts associated with these commonly used surgical treatments and to determine whether the type of surgery influences the recovery or disruption of the subgingival ecosystem.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Age 18 years or older
- Confirmed diagnosis of Peri-implantitis (for the peri-implantitis surgery arm), or Stage III/IV periodontitis (for the periodontal surgery arms)
- Indication for surgical therapy corresponding to the assigned study arm
- Ability to understand the study procedures and provide written informed consent
- Adequate oral hygiene (API/SBI according to the clinician's judgment)
You likely can't join if
- Systemic conditions contraindicating oral surgical procedures
- Severe systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders)
- Use of systemic antibiotics within the previous 3 months
- Active COVID-19 infection at the time of surgery
- Pregnancy or breastfeeding
- Drug or alcohol abuse
See the full eligibility criteria
- Age 18 years or older
- Confirmed diagnosis of Peri-implantitis (for the peri-implantitis surgery arm), or Stage III/IV periodontitis (for the periodontal surgery arms)
- Indication for surgical therapy corresponding to the assigned study arm
- Ability to understand the study procedures and provide written informed consent
- Adequate oral hygiene (API/SBI according to the clinician's judgment)
- Willingness and ability to attend all follow-up visits
- Willingness to provide salivary and subgingival plaque samples for microbiome analyses (NGS, SMDI)
- Systemic conditions contraindicating oral surgical procedures
- Severe systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders)
- Use of systemic antibiotics within the previous 3 months
- Active COVID-19 infection at the time of surgery
- Pregnancy or breastfeeding
- Drug or alcohol abuse
- Smoking more than 10 cigarettes per day
- Known allergies to materials used in the assigned intervention (e.g., local anesthetics, sutures, membranes, bone grafting materials)
- Participation in another clinical study within the previous 30 days
- Acute oral infections that contraindicate participation
- Inability or unwillingness to comply with all follow-up appointments Lack of capacity to provide informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Münster, North Rhine-Westphalia, Germany
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Münster, North Rhine-Westphalia, Germany. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.