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New treatment option for Tooth Loss
Official title Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin
ClinicalTrials.gov ID: NCT07393997
What this study is testing
- What it's testing
- Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth. This approach preserves alveolar bone volume, maintains periodontal proprioception, and allows physiological adaptation over time.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 10 to 80. Healthy volunteers may be eligible.
You may be able to join if
- Autotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:
- Early loss of permanent teeth due to trauma, extensive caries, or agenesis.
- Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.
- Replacement of non-restorable teeth (fractures or destructive caries).
- Preservation of alveolar bone in growing patients where implant therapy is contraindicated.
You likely can't join if
- Poor patient compliance.
- Active infection at the recipient site.
- Smoking of more than 15 cigarettes a day . Untreated periodontal disease
- Pregnancy or breastfeeding at date of inclusion
- Acute infections
See the full eligibility criteria
- Autotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:
- Early loss of permanent teeth due to trauma, extensive caries, or agenesis.
- Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.
- Replacement of non-restorable teeth (fractures or destructive caries).
- Preservation of alveolar bone in growing patients where implant therapy is contraindicated.
- Functional and aesthetic rehabilitation of anterior teeth in pediatric and adolescent patients.
- Post-traumatic oral rehabilitation in young patients.
- Good general and oral health.
- Presence of a vital and intact periodontal ligament on the donor tooth.
- Adequate recipient site dimensions and morphology, or surgically adaptable.
- Absence of active infection at the recipient site. Donor Tooth Selection Criteria
- Tooth extracted for orthodontic purposes.
- Impacted or erupting third molars with compatible morphology.
- Suitable supernumerary teeth.
- Poor patient compliance.
- Active infection at the recipient site.
- Smoking of more than 15 cigarettes a day . Untreated periodontal disease
- Pregnancy or breastfeeding at date of inclusion
- Acute infections
The study team makes the final eligibility decision.
Where it's taking place
- Bari, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 10 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bari, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.