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Tests treatment safety and results for Senile Deadness
Official title Efficacy and Safety of rTMS Combined With HA in the Treatment of Cognitive Decline in Aged Related Hearing Loss
ClinicalTrials.gov ID: NCT07389213
What this study is testing
- What it's testing
- This study is a real-world interventional trial enrolling 189 participants: older adults with age-related hearing loss not using hearing aids (ARHL-nonHA), those using hearing aids (ARHL-HA), and those with normal hearing (HC). All groups will undergo hearing, cognitive (MMSE, MoCA, SCWT, DST, TMT), depression (GDS-15, HAMD-24), sleep (PSQI), and brain imaging (EEG, sMRI, rs-fMRI, task-fMRI) assessments.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 85. Healthy volunteers may be eligible.
You may be able to join if
- Age ≥50 years and ≤85 years, regardless of gender.
- Diagnosed with age-related hearing loss (ARHL), characterized by symmetrical, slowly progressing hearing loss primarily affecting high frequencies...
- The better ear has moderate, moderately severe, or severe hearing loss (based on the 2021 WHO hearing classification standards, i.e., PTA between...
- Wearing hearing aids for more than half a year, with daily wearing time exceeding 7.2 hours; (Only ARHL-HA group)
- Chinese nationals who can complete all assessments in Chinese.
You likely can't join if
- Exclusion of hearing loss due to noise, genetics, ototoxic drugs, or other non-age-related causes;
- History of central nervous system disorders such as cerebral infarction, stroke, epilepsy, or traumatic brain injury;
- Diagnosis of dementia or other neurodegenerative diseases that affect compliance with the study;
- Presence of major neurological disorders, severe systemic diseases, family history of hereditary conditions, or major psychiatric disorders;
- Contraindications to MRI;
- Contraindications to rTMS.
See the full eligibility criteria
- Age ≥50 years and ≤85 years, regardless of gender.
- Diagnosed with age-related hearing loss (ARHL), characterized by symmetrical, slowly progressing hearing loss primarily affecting high frequencies, along with decreased speech recognition ability due to aging. This is...
- The better ear has moderate, moderately severe, or severe hearing loss (based on the 2021 WHO hearing classification standards, i.e., PTA between 35～79dB).
- Wearing hearing aids for more than half a year, with daily wearing time exceeding 7.2 hours; (Only ARHL-HA group)
- Chinese nationals who can complete all assessments in Chinese.
- Right-handed.
- Educational level of at least 6 years.
- Informed consent obtained, agreeing to participate in the trial with no plans to relocate within one year.
- Exclusion of hearing loss due to noise, genetics, ototoxic drugs, or other non-age-related causes;
- History of central nervous system disorders such as cerebral infarction, stroke, epilepsy, or traumatic brain injury;
- Diagnosis of dementia or other neurodegenerative diseases that affect compliance with the study;
- Presence of major neurological disorders, severe systemic diseases, family history of hereditary conditions, or major psychiatric disorders;
- Contraindications to MRI;
- Contraindications to rTMS.
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 85 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.