BridgeMD
Compares treatment options for Major Depressive Disorder (MDD)
Official title Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy Approaches
ClinicalTrials.gov ID: NCT07388004
What this study is testing
- What it's testing
- Major depressive disorder (MDD) is one of the most common psychiatric conditions and often remains difficult to treat effectively. Many patients continue to experience residual symptoms or relapse even after receiving established forms of psychotherapy.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Age: 18-80 years
- Current diagnosis of major depressive disorder (MDD) according to DSM-5, confirmed by structured clinical interview (e.g., DIPS)
- Hamilton Depression Rating Scale (HAMD-21) score ≥ 9
- Ability to attend group therapy sessions (2×/week for 5 weeks)
- Ability to undergo MRI scanning (for participants in the fMRI component) Written informed consent
You likely can't join if
- Current or lifetime diagnosis of bipolar disorder, psychotic disorder, or primary substance use disorder
- High acute suicide risk requiring immediate intervention
- Severe neurological disorder, brain injury, or contraindications for MRI (e.g., metal implants, claustrophobia)
- Ongoing psychotherapy or initiation of a new antidepressant medication within the past 4 weeks
- Insufficient German language proficiency to participate in therapy and complete study assessments
- Cognitive impairment or other conditions interfering with informed consent or study participation
The study team makes the final eligibility decision.
Where it's taking place
- Marburg, Hesse, Germany
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Marburg, Hesse, Germany. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.