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New treatment option for Drug Discontinuation
Official title Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation
ClinicalTrials.gov ID: NCT07387796
What this study is testing
- What it's testing
- The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages 18-70 who are currently taking tirzepatide. Specifically, the study aims to examine how a short pause in tirzepatide affects hunger, mood, sleep, and daily functioning; how stopping and restarting tirzepatide alters brain chemistry and brain responses to food-related images; and how these changes relate to health measures such as quality of life and emotional well-being.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Aged 18-70 years.
- Currently on tirzepatide.
- Currently receiving care from University of Texas- Southwestern (UTSW) Weight Wellness Clinic.
- Cognitively capable of understanding and signing informed consent.
- Be proficient in English.
You likely can't join if
- History of major neurological or psychiatric disorders, including substance use disorders that might confound brain imaging results (e.g., stroke...
- Diagnosis of Type 2 Diabetes.
- Current diagnosis of an eating disorder.
- Use of medications affecting weight other than tirzepatide.
- Pregnancy or breastfeeding.
- MR contraindications:
See the full eligibility criteria
- Aged 18-70 years.
- Currently on tirzepatide.
- Currently receiving care from University of Texas- Southwestern (UTSW) Weight Wellness Clinic.
- Cognitively capable of understanding and signing informed consent.
- Be proficient in English.
- History of major neurological or psychiatric disorders, including substance use disorders that might confound brain imaging results (e.g., stroke, epilepsy, multiple sclerosis, schizophrenia, major depression requiring...
- Diagnosis of Type 2 Diabetes.
- Current diagnosis of an eating disorder.
- Use of medications affecting weight other than tirzepatide.
- Pregnancy or breastfeeding.
- MR contraindications:
- Heart pacemaker, heart valve replacement, or aortic clips
- Metal fragments in the eyes, skin, or elsewhere in the body
- Brain clips or pieces of metal used in aneurysm surgery or intercranial bypass
- Venous umbrella
- Pieces of metal in the body resulting from work as a sheet-metal worker or welder
- Clips placed in an internal organ
- Prosthetic devices, such as middle ear, eye, joint, or penile implants
- Joint replacement
- Hearing aid that cannot be removed
- Neurostimulator
- Insulin pump
- Shunts or stents
- Metal mesh or coil implants
- Metal plate, pin, screws, or wires, or any other metal implants
The study team makes the final eligibility decision.
Where it's taking place
- Dallas, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dallas, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.