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New treatment option for Aortic Dissection Type A
Official title Remote Ischemic Preconditioning for Aute Type A Aortic Dissection Surgery
ClinicalTrials.gov ID: NCT07383909
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn if a technique called remote ischemic preconditioning (RIPC) helps protect organs during emergency surgery for acute type A aortic dissection (ATAAD). The main questions it aims to answer are: Does RIPC reduce the risk of major complications after surgery, such as heart, brain, or kidney problems?
- Time commitment: about 5 years
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years, with no restriction on sex;
- Diagnosis of acute Type A aortic dissection requiring emergency surgery (symptom onset \<14 days);
- Ability to understand the study objectives, voluntary provision of written informed consent by the patient or a legally authorized representative...
You likely can't join if
- Traumatic or iatrogenic aortic dissection;
- Previous open cardiac or thoracic aortic surgery;
- Severe preoperative dysfunction of vital organs, such as persistent deep coma, abdominal compartment syndrome, or circulatory failure;
- Severe comorbidities, including myocardial infarction within the past 7 days, stroke within the past 2 months; end-stage renal disease (eGFR \ 342...
- Evidence of ischemia in the limb planned for intervention, such as decreased skin temperature, pain, pallor, with or without sensory disturbance...
- Peripheral arterial disease involving the limbs, Raynaud phenomenon, active phlebitis, or a history of deep vein thrombosis of the lower extremities;
See the full eligibility criteria
- Age ≥18 years, with no restriction on sex;
- Diagnosis of acute Type A aortic dissection requiring emergency surgery (symptom onset \<14 days);
- Ability to understand the study objectives, voluntary provision of written informed consent by the patient or a legally authorized representative, and willingness to comply with follow-up.
- Traumatic or iatrogenic aortic dissection;
- Previous open cardiac or thoracic aortic surgery;
- Severe preoperative dysfunction of vital organs, such as persistent deep coma, abdominal compartment syndrome, or circulatory failure;
- Severe comorbidities, including myocardial infarction within the past 7 days, stroke within the past 2 months; end-stage renal disease (eGFR \ 342 μmol/L or INR \>2.0);
- Evidence of ischemia in the limb planned for intervention, such as decreased skin temperature, pain, pallor, with or without sensory disturbance, paralysis, or diminished/absent pulses; or severe deformity or prior...
- Peripheral arterial disease involving the limbs, Raynaud phenomenon, active phlebitis, or a history of deep vein thrombosis of the lower extremities;
- Current use of sulfonylurea oral hypoglycemic agents or nicorandil;
- Life expectancy \<1 year (e.g., advanced malignancy);
- Participation in another clinical trial without having reached its primary endpoint;
- Pregnancy or lactation; immunodeficiency (e.g., HIV positivity, history of organ transplantation); known bleeding disorders, coagulation abnormalities, or sickle cell anemia; active or uncontrolled infection;
- Other severe physical or psychiatric disorders, or laboratory abnormalities, which in the investigator's judgment may increase risk or interfere with study outcomes, rendering the patient unsuitable for enrollment.
The study team makes the final eligibility decision.
Where it's taking place
- Fuzhou, Fujian, China
- Xiamen, Fujian, China
- Dalian, Liaoning, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 5 years per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Fuzhou, Fujian, China; Xiamen, Fujian, China; Dalian, Liaoning, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.