BridgeMD
New treatment option for Aesthetic
Official title Aesthetic Improvement of Facial Rhytids Using Injectables
ClinicalTrials.gov ID: NCT07383766
What this study is testing
- What it's testing
- Revanesse® Renew™+ (Prollenium Medical Technologies Inc.) is a non-crosslinked HA skin booster that combines low- and high-molecular-weight HA at a concentration of 14 mg/mL in a sterile aqueous gel for intradermal injection7. This dual-weight formulation provides both rapid hydration and sustained moisture retention, improving dermal suppleness and promoting subtle textural refinement through physiologic hydration rather than volumization.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 75. Healthy volunteers may be eligible.
You may be able to join if
- Ability to adequately understand the verbal explanations and the written participant information provided in local language and ability and...
- Participant interested in improving skin quality.
- Immune-competent adult 30 years of age and older.
- Has intent to undergo treatment to improve appearance of the facial skin.
- Willingness to comply with pre-visit instructions, including shaving of facial area (for male participants), to allow for consistent biometric and...
You likely can't join if
- Known or suspected allergy or hypersensitivity to any components of Revanesse® Renew™+
- Known allergy or intolerance to topical anesthetics or lidocaine.
- History of hypersensitivity reactions such as anaphylaxis, angioedema, or other severe allergic responses.
- History of hypertrophic scarring, keloid formation, or post-inflammatory hyperpigmentation following cosmetic treatments.
- Tattoos, piercings, or skin bleaching agents in the treatment area that may interfere with assessments, as judged by the Investigator.
- Previous cosmetic or dermatologic procedures in the treatment area within the following time frames:
See the full eligibility criteria
Who can join
- Ability to adequately understand the verbal explanations and the written participant information provided in local language and ability and willingness to give consent to participate in the study. Signed and dated...
- Participant interested in improving skin quality.
- Immune-competent adult 30 years of age and older.
- Has intent to undergo treatment to improve appearance of the facial skin.
- Willingness to comply with pre-visit instructions, including shaving of facial area (for male participants), to allow for consistent biometric and photographic evaluations.
- If the participant is a female of childbearing potential, she agrees to use an acceptable form of effective birth control for the duration of the study and is willing to take a urine pregnancy test (UPT) at Baseline and...
- Barrier methods of contraception: Condom or occlusive cap (diaphragm or cervical caps) with spermicidal foam/gel/film/ cream/suppository;
- Bilateral tubal ligation;
- Combined oral contraceptives (estrogens and progesterone), implanted or injectable contraceptives on a stable dose for at least 28 days prior to Day 1;
- Hormonal or copper intra uterine device (IUD) inserted at least 28 days prior to Day 1;
- Vasectomized partner (in monogamous relationship) for at least 3 months prior to screening;
- Strict abstinence (at least one month prior to Baseline and agrees to continue for the duration of the study or use acceptable form of birth control).
- Negative UPT for women of childbearing potential at the Baseline visit.
- Stable lifestyle and skincare regimen for at least 4 weeks
What rules you out
- Known or suspected allergy or hypersensitivity to any components of Revanesse® Renew™+
- Known allergy or intolerance to topical anesthetics or lidocaine.
- History of hypersensitivity reactions such as anaphylaxis, angioedema, or other severe allergic responses.
- History of hypertrophic scarring, keloid formation, or post-inflammatory hyperpigmentation following cosmetic treatments.
- Tattoos, piercings, or skin bleaching agents in the treatment area that may interfere with assessments, as judged by the Investigator.
- Previous cosmetic or dermatologic procedures in the treatment area within the following time frames:
- Previous treatment with cross-linked hyaluronic acid dermal fillers in the treatment area within the last 12 months.
- Energy-based devices (laser, IPL, RF, ultrasound) in the last 6 months.
- Microneedling, dermabrasion, mesotherapy, or chemical peels in the last 6 months.
- Use of topical corticosteroids, retinoids, or depigmenting agents in the treatment area within the past 4 weeks.
- Current use of immunosuppressive therapy, systemic corticosteroids, or chemotherapy within the last 3 months.
- History of systemic autoimmune, collagen vascular, or bleeding disorders (e.g., lupus, scleroderma, thrombocytopenia).
- Current pregnancy, positive urine pregnancy test at screening, breastfeeding, or intent to become pregnant during the study.
- Participation in another clinical study within the past 30 days or concurrent participation in another treatment trial.
- Any condition, including psychological, cognitive, or behavioral concerns, that would interfere with the ability to give informed consent, follow the protocol, or comply with follow-up requirements.
- Initiation of a weight loss program or GLP-1 agonist therapy within 30 days before baseline or planned during study period.
- Current participation by study personnel, immediate family members, or employees of the Sponsor.
- History of cancer or previous radiation near or on the area to be treated.
- Heavy smokers, classified as smoking more than 12 cigarettes per day.
- Presence of any disease or lesions near or on the area to be treated, e.g.
- Inflammation, active or chronic infection in or near the treatment area
- Psoriasis, eczema, herpes zoster and acanthosis
- Cancer or precancerous condition (e.g. actinic keratosis)
- Severe skin laxity, flaccidity, or sagging
- Advanced photoaged/ photodamaged skin (e.g., advanced skin elastosis, multiple lentigo solaris lesions) or skin condition (e.g., very crinkled, very thin, fragile skin or severe skin atrophy) in the treatment area that...
- Skin coloring/bleaching/tattoo in the treatment area, which, in the Treating Investigator's opinion, would interfere with the study injections and/or study assessment.
- An underlying known disease, a surgical or medical condition that would expose the participant to undue risk, e.g. history of bleeding disorders, active hepatitis, active autoimmune disease such as connective tissue...
- Use of concomitant medication that have the potential to prolong bleeding times such as anticoagulants or inhibitors of platelet aggregation (e.g., warfarin, clopidogrel, aspirin, baby aspirin, nonsteroidal...
- Treatment with chemotherapy, immunosuppressive agents, systemic corticosteroids within 3 months before treatment (inhaled or ophthalmic corticosteroids are allowed).
- Use of hormonal therapy (ex. HRT or contraceptives) unless the participant has been on a stable dose for at least 3 months prior to screening and does not plan to make any changes to the HRT regimen during the study...
- Pregnancy (confirmed by positive urine pregnancy test (UPT)/ serum pregnancy test), breast feeding or intends to become pregnant over the duration of the study.
The study team makes the final eligibility decision.
Where it's taking place
- Montreal, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Montreal, Quebec, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.