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Compares treatment options for Delayed Sequence Intubation
Official title Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols
ClinicalTrials.gov ID: NCT07380763
What this study is testing
- What it's testing
- This study compares two different methods of helping patients breathe by placing a tube in their airway (intubation) in an emergency setting. These methods are called Rapid Sequence Intubation (RSI) and Delayed Sequence Intubation (DSI).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Aged 18 years or older
- Presence of spontaneous breathing.
- No prediction of a difficult airway prior to intubation.
- Requirement for advanced airway management.
- Not in cardiac arrest.
You likely can't join if
- Aged under 18 years.
- Pregnancy.
- Refusal to provide informed consent.
- Cardiac arrest prior to intubation.
- Anticipated difficult airway.
- Intubation required due to traumatic etiologies.
See the full eligibility criteria
- Aged 18 years or older
- Presence of spontaneous breathing.
- No prediction of a difficult airway prior to intubation.
- Requirement for advanced airway management.
- Not in cardiac arrest.
- Decided to intubate due to non-traumatic etiologies.
- Planned intubation using ketamine for sedation and rocuronium for paralysis.
- Decision to intubate due to one of the following clinical conditions:
- Acute Respiratory Failure: Patients with hypoxic or hypercapnic respiratory failure where adequate oxygenation cannot be achieved despite non-invasive ventilation.
- Inability to Protect the Airway: Altered level of consciousness or increased risk of pulmonary aspiration due to conditions such as upper gastrointestinal bleeding, ileus, volvulus, gastric outlet obstruction...
- Shock States: Patients in any state of shock (hypovolemic, distributive, cardiogenic, obstructive) exhibiting severe altered mental status or declining respiratory status.
- Neuroprotection: Need to terminate ongoing seizures resistant to medical therapy (status epilepticus), or situations requiring strict control of arterial carbon dioxide (PaCO₂) levels to manage increased intracranial...
- Obtaining informed consent from the patient or their legally authorized representative.
- Aged under 18 years.
- Pregnancy.
- Refusal to provide informed consent.
- Cardiac arrest prior to intubation.
- Anticipated difficult airway.
- Intubation required due to traumatic etiologies.
- Missing or incomplete patient data.
- Patients assigned to the DSI protocol but for whom the decision to intubate was rescinded due to clinical improvement during the preoxygenation phase.
- Use of a sedative agent other than ketamine for the RSI protocol.
- Intubations performed by practitioners who have not received study-specific training on DSI and RSI protocols.
- Duplicate enrollment due to recurrent presentations during the study period.
The study team makes the final eligibility decision.
Where it's taking place
- Istanbul, Istanbul, Turkey (Türkiye)
- Istanbul, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Istanbul, Istanbul, Turkey (Türkiye); Istanbul, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.