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New treatment option for Atypical Endometrial Hyperplasia
Official title Intrauterine Injection of Type III Collage in FST of EC/AEH
ClinicalTrials.gov ID: NCT07377734
What this study is testing
What is Recombinant Humanized Type III Collagen Lyophilized Fibers + High-dose Progestin?
Recombinant Humanized Type III Collagen Lyophilized Fibers + High-dose Progestin is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for atypical endometrial hyperplasia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if intrauterine injection of "Recombinant Humanized Type III Collagen Lyophilized Fibers" works to treat endometrial cancer or atypical hyperplasia in patients seeking fertility-preserving treatment. It will also learn about the safety of this intervention.The main questions it aims to answer are: 1.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 45, women only
You may be able to join if
- Pathological diagnosis of endometrioid adenocarcinoma (G1 or G2) or atypical endometrial hyperplasia.
- For patients with endometrial cancer, magnetic resonance imaging (MRI) or ultrasound must confirm that the lesion is confined to the endometrium or...
- Age ≤ 45 years.
- Desire to preserve fertility and signed informed consent.
- No serious medical comorbidities (e.g., severe liver or renal dysfunction).
You likely can't join if
- Tumor invasion \> 1/2 of the myometrium, or FIGO (2009) Stage IB and above.
- Tumor differentiation grade G3 or non-endometrioid adenocarcinoma.
- Coexistence of other malignant tumors.
- Contraindications to conservative treatment or use of the study drugs.
- Known allergy to recombinant protein components.
- Acute genital tract inflammation or untreated abnormal vaginal discharge within 2 weeks prior to enrollment.
See the full eligibility criteria
- Pathological diagnosis of endometrioid adenocarcinoma (G1 or G2) or atypical endometrial hyperplasia.
- For patients with endometrial cancer, magnetic resonance imaging (MRI) or ultrasound must confirm that the lesion is confined to the endometrium or invades less than 1/2 of the myometrium (i.e., FIGO 2009 Stage IA).
- Age ≤ 45 years.
- Desire to preserve fertility and signed informed consent.
- No serious medical comorbidities (e.g., severe liver or renal dysfunction).
- No contraindications to progestin therapy or pregnancy.
- No evidence of distant metastasis on imaging.
- Tumor invasion \> 1/2 of the myometrium, or FIGO (2009) Stage IB and above.
- Tumor differentiation grade G3 or non-endometrioid adenocarcinoma.
- Coexistence of other malignant tumors.
- Contraindications to conservative treatment or use of the study drugs.
- Known allergy to recombinant protein components.
- Acute genital tract inflammation or untreated abnormal vaginal discharge within 2 weeks prior to enrollment.
- Previous treatment with high-potency progestin for more than 1 month.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 45 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.