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New treatment option for Hyperoxemia
Official title HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
ClinicalTrials.gov ID: NCT07377162
What this study is testing
- What it's testing
- This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU). Many ICU patients receive more oxygen than strictly necessary, and high blood oxygen levels (hyperoxemia) are very common.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patients aged ≥18 years
- Admitted to the intensive care unit (ICU)
- Intubated and mechanically ventilated for ≤72 hours
- Receiving volume-controlled mechanical ventilation
- Arterial partial pressure of carbon dioxide (PaCO₂) between 35 and 45 mmHg
You likely can't join if
- Age \<18 years
- Pregnancy
- Extracorporeal membrane oxygenation (ECMO)
- Continuous renal replacement therapy (CRRT)
- Contraindications to hyperoxia, as judged by the treating physician
- Severe hemodynamic instability requiring changes in vasopressor dose during the recording period
See the full eligibility criteria
- Adult patients aged ≥18 years
- Admitted to the intensive care unit (ICU)
- Intubated and mechanically ventilated for ≤72 hours
- Receiving volume-controlled mechanical ventilation
- Arterial partial pressure of carbon dioxide (PaCO₂) between 35 and 45 mmHg
- Invasive arterial blood pressure monitoring in place
- Adequate transcranial Doppler (TCD) acoustic window
- Clinically judged to be suitable for a brief normobaric hyperoxic stimulus
- Expected to receive one or two hyperoxic steps based on baseline FiO₂ requirements: a) Baseline FiO₂ \< 0.5: two-step hyperoxic stimulus (FiO₂ 0.5 followed by FiO₂ 1.0); b) Baseline FiO₂ ≥ 0.5: one-step hyperoxic...
- Age \<18 years
- Pregnancy
- Extracorporeal membrane oxygenation (ECMO)
- Continuous renal replacement therapy (CRRT)
- Contraindications to hyperoxia, as judged by the treating physician
- Severe hemodynamic instability requiring changes in vasopressor dose during the recording period
- Inability to obtain a reliable transcranial Doppler signal through the temporal acoustic windows
- Any clinical condition deemed by the treating physician to pose unacceptable risk during hyperoxic exposure
The study team makes the final eligibility decision.
Where it's taking place
- Brussels, Belgium
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Brussels, Belgium. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.