BridgeMD
New treatment option for Keratoconus
Official title PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus
ClinicalTrials.gov ID: NCT07372911
What this study is testing
- What it's testing
- Keratoconus causes irregular astigmatism and reduced vision. Epi-off corneal crosslinking (CXL) stabilizes the cornea but often leaves higher-order aberrations uncorrected.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18-40 years
- Diagnosis of keratoconus, ABCD Belin stage I-III at baseline
- Minimum (thinnest) corneal pachymetry ≥ 450 µm pre-op
- Written informed consent
- Age-stratified progression requirements:
You likely can't join if
- Central corneal scars or opacities
- Prior ocular surgery or trauma (exception: prior LASIK if it is the cause of post-surgical ectasia, per protocol text)
- Autoimmune disease or uncontrolled diabetes mellitus
- Pregnancy or lactation
- Contact lens wear within 2 weeks before baseline evaluation
See the full eligibility criteria
- Age 18-40 years
- Diagnosis of keratoconus, ABCD Belin stage I-III at baseline
- Minimum (thinnest) corneal pachymetry ≥ 450 µm pre-op
- Written informed consent
- Age-stratified progression requirements:
- 18-25 y: keratoconus stage I-III (progression not mandatory)
- 25-35 y: documented progression (meet ≥ 2 Table-1 criteria below) or, if recent documentation is absent, high-risk features for future progression: Kmax \> 53 D, strong family history, severe atopy with persistent eye...
- 35-40 y: clear, unequivocal recent progression (meet ≥ 2 Table-1 criteria); late-onset documented progression may be considered
- Central corneal scars or opacities
- Prior ocular surgery or trauma (exception: prior LASIK if it is the cause of post-surgical ectasia, per protocol text)
- Autoimmune disease or uncontrolled diabetes mellitus
- Pregnancy or lactation
- Contact lens wear within 2 weeks before baseline evaluation
The study team makes the final eligibility decision.
Where it's taking place
- Mexico City, Mexico City, Mexico
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Mexico City, Mexico City, Mexico. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.