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Tests treatment safety and results for Herpes Zoster
Official title The Analgesic Efficacy and Safety of Tulodesvenlafaxine in Patients With Herpes Zoster
ClinicalTrials.gov ID: NCT07370389
What this study is testing
What is Conventional therapy group?
Conventional therapy group is an investigational medicine, being studied as a potential treatment for herpes zoster.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- 1\. Ages more than 18 years;
- 2\. Patients with onset of HZ rash less than 90 days;
- 3\. Experiencing moderate to severe HZ pain with an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10 = worst possible...
- 4\. Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
- 5\. Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
You likely can't join if
- 1\. History of taking tulodesvenlafaxine;
- 2\. Patients with evidence of cutaneous or visceral dissemination of HZ infection (cutaneous dissemination is defined as more than 20 discrete...
- 3\. History of intolerance or hypersensitivity to any active components or excipient of the tulodesvenlafaxine;
- 4\. History of systemic immune diseases, organ transplantation, or cancers;
- 5\. Pregnancy or breastfeeding;
- 6\. Suffering from acute or chronic pain disorders other than HZ.
See the full eligibility criteria
- 1\. Ages more than 18 years;
- 2\. Patients with onset of HZ rash less than 90 days;
- 3\. Experiencing moderate to severe HZ pain with an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10 = worst possible pain);
- 4\. Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
- 5\. Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
- 6\. Willing to sign the informed consent form and possessing sufficient cognitive and language abilities to comply with all the study requirements.
- 1\. History of taking tulodesvenlafaxine;
- 2\. Patients with evidence of cutaneous or visceral dissemination of HZ infection (cutaneous dissemination is defined as more than 20 discrete lesions outside adjacent dermatomes) or ocular involvement of HZ;
- 3\. History of intolerance or hypersensitivity to any active components or excipient of the tulodesvenlafaxine;
- 4\. History of systemic immune diseases, organ transplantation, or cancers;
- 5\. Pregnancy or breastfeeding;
- 6\. Suffering from acute or chronic pain disorders other than HZ.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.