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Compares treatment options for Premature Rupture of Fetal Membranes
Official title PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)
ClinicalTrials.gov ID: NCT07366359
What this study is testing
What is Sequential Induction: Dinoprostone Followed by Oxytocin?
Sequential Induction: Dinoprostone Followed by Oxytocin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for premature rupture of fetal membranes.
Also referred to as Dinoprostone (Propess).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM). When this happens and the cervix is not ready for labor, it is unclear which induction method works best and is safest for mother and baby.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, women only
You may be able to join if
- Maternal age ≥ 18 years
- Gestational age from 37 to 42 weeks, determined by last menstrual period or by a first- or second-trimester ultrasound
- Live singleton fetus
- Prelabor rupture of membranes (PROM) confirmed by at least one of the following:
- Amniotic fluid visibly draining from the cervical os during sterile speculum examination
You likely can't join if
- Active labor
- Previous uterine surgery (e.g., cesarean section)
- Chorioamnionitis or non-reassuring fetal status
- Major fetal anomalies
- Contraindications to prostaglandin or vaginal delivery
- Refusal to participate
See the full eligibility criteria
- Maternal age ≥ 18 years
- Gestational age from 37 to 42 weeks, determined by last menstrual period or by a first- or second-trimester ultrasound
- Live singleton fetus
- Prelabor rupture of membranes (PROM) confirmed by at least one of the following:
- Amniotic fluid visibly draining from the cervical os during sterile speculum examination
- Pool of fluid in the posterior fornix
- Cephalic presentation
- Bishop score ≤ 6
- No spontaneous uterine contractions
- No contraindications for vaginal delivery
- Active labor
- Previous uterine surgery (e.g., cesarean section)
- Chorioamnionitis or non-reassuring fetal status
- Major fetal anomalies
- Contraindications to prostaglandin or vaginal delivery
- Refusal to participate
The study team makes the final eligibility decision.
Where it's taking place
- Hanoi, Hanoi, Vietnam
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hanoi, Hanoi, Vietnam. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.