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Tests treatment safety and results for Cervicogenic Headache
Official title Effectiveness of Third Occipital Nerve Pulsed Radiofrequency in Cervicogenic Headache
ClinicalTrials.gov ID: NCT07366060
What this study is testing
- What it's testing
- Cervicogenic headache is a secondary headache disorder originating from cervical spine structures and is frequently associated with chronic pain, functional limitation, and impaired quality of life. The third occipital nerve, which innervates the C2-3 zygapophyseal joint, plays an important role in the pathophysiology of cervicogenic headache.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18 years or older
- Diagnosis of cervicogenic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
- Availability of cranial and cervical spine imaging
- At least 5 headache days per month
- Inadequate response to pharmacological and/or physical therapy treatments
You likely can't join if
- Secondary headache disorders other than cervicogenic headache according to ICHD-3
- Signs or symptoms of cervical nerve root irritation and/or spinal stenosis
- Sensory deficit in the greater occipital nerve dermatome
- Cranio-cervical structural defects or anatomical abnormalities at or near the target site
- Local or systemic infection
- Non-pharmacological headache treatment within the last 3 months (e.g., physical therapy, botulinum toxin A, acupuncture, ozone therapy, cognitive...
See the full eligibility criteria
- Age 18 years or older
- Diagnosis of cervicogenic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
- Availability of cranial and cervical spine imaging
- At least 5 headache days per month
- Inadequate response to pharmacological and/or physical therapy treatments
- Ability to understand and provide written informed consent
- Positive response to ultrasound-guided diagnostic third occipital nerve block, defined as at least 50% reduction in pain intensity or patient-reported meaningful improvement
- Secondary headache disorders other than cervicogenic headache according to ICHD-3
- Signs or symptoms of cervical nerve root irritation and/or spinal stenosis
- Sensory deficit in the greater occipital nerve dermatome
- Cranio-cervical structural defects or anatomical abnormalities at or near the target site
- Local or systemic infection
- Non-pharmacological headache treatment within the last 3 months (e.g., physical therapy, botulinum toxin A, acupuncture, ozone therapy, cognitive behavioral therapy)
- Pregnancy or suspected pregnancy
- Known allergy to local anesthetic agents
- History of malignancy
- Known organic disease of the brain or spinal cord
- History of cranial or cervical surgery within the last 12 months
- Bleeding or coagulation disorders or use of oral anticoagulant therapy
- Comorbid conditions that may cause headache (e.g., uncontrolled hypertension, intracranial lesions)
- Conditions that may interfere with treatment adherence or outcome assessment (e.g., psychiatric disorders, dementia)
- Request for re-treatment due to development of contralateral pain or other pain conditions during follow-up
- Refusal to undergo the intervention or withdrawal of consent at any stage of the study
The study team makes the final eligibility decision.
Where it's taking place
- Ankara, Ankara, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ankara, Ankara, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.