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Prevention study for Herpes Zoster
Official title The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster
ClinicalTrials.gov ID: NCT07361796
What this study is testing
What is Venlafaxine combined conventional therapy?
Venlafaxine combined conventional therapy is an investigational medicine, given as an once-daily treatment applied to the skin, being studied as a potential treatment for herpes zoster.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) and represents a major clinical challenge due to its chronicity and impact on quality of life. Current treatments for acute HZ pain have limited efficacy in preventing PHN, highlighting the need for effective preventive strategies targeting early pathophysiological mechanisms.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- 1\. Ages more than 18 years;
- 2\. Patients with onset of HZ rash less than 30 days;
- 3\. Experiencing moderate to severe HZ pain with an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10 = worst possible...
- 4\. Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
- 5\. Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
You likely can't join if
- 1\. HZ with head, neck, ocular, mucous membrane, cranial nerve, or central nervous system involvement or generalized HZ;
- 2.Known hypersensitivity to venlafaxine;
- 3.History of major depressive disorder requiring antidepressant therapy;
- 4.History of systemic immune diseases, organ transplantation, or cancers;
- 5.Pregnancy or lactation;
- 6.Presence of acute or chronic pain disorders other than HZ.
See the full eligibility criteria
- 1\. Ages more than 18 years;
- 2\. Patients with onset of HZ rash less than 30 days;
- 3\. Experiencing moderate to severe HZ pain with an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10 = worst possible pain);
- 4\. Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
- 5\. Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
- 6\. Willing to sign the informed consent form and possessing sufficient cognitive and language abilities to comply with all the study requirements.
- 1\. HZ with head, neck, ocular, mucous membrane, cranial nerve, or central nervous system involvement or generalized HZ;
- 2.Known hypersensitivity to venlafaxine;
- 3.History of major depressive disorder requiring antidepressant therapy;
- 4.History of systemic immune diseases, organ transplantation, or cancers;
- 5.Pregnancy or lactation;
- 6.Presence of acute or chronic pain disorders other than HZ.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.