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New treatment option for Postoperative Delirium (POD)
Official title Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
ClinicalTrials.gov ID: NCT07357480
What this study is testing
- What it's testing
- This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients undergoing supratentorial surgery. Propofol and remifentanil are administered using either target-controlled or manual infusion techniques according to the study protocol.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- Adult patients aged 18 to 60 years
- Scheduled for elective supratentorial surgery under general anesthesia
- American Society of Anesthesiologists (ASA) physical status I or II
- Planned total intravenous anesthesia with propofol and remifentanil
- Ability to provide written informed consent
You likely can't join if
- Refusal or inability to provide written informed consent
- American Society of Anesthesiologists (ASA) physical status III or higher
- Pregnancy
- Emergency surgery
- Presence of brain herniation
- Anticipated or documented difficult airway
See the full eligibility criteria
- Adult patients aged 18 to 60 years
- Scheduled for elective supratentorial surgery under general anesthesia
- American Society of Anesthesiologists (ASA) physical status I or II
- Planned total intravenous anesthesia with propofol and remifentanil
- Ability to provide written informed consent
- Refusal or inability to provide written informed consent
- American Society of Anesthesiologists (ASA) physical status III or higher
- Pregnancy
- Emergency surgery
- Presence of brain herniation
- Anticipated or documented difficult airway
- Inability to communicate effectively (e.g., non-Turkish speaking or hearing impairment)
- Preoperative risk factors for delirium, including substance abuse, use of neuropsychiatric medications, preoperative hemoglobin level \< 8 g/dL, malnutrition, or electrolyte or thyroid hormone abnormalities
- Intraoperative deviation from the study protocol, including changes in surgical or anesthetic technique or occurrence of major intraoperative complications
- Contraindications to propofol or remifentanil
The study team makes the final eligibility decision.
Where it's taking place
- Istanbul, Bakırköy, Turkey (Türkiye)
- Istanbul, Istanbul, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Istanbul, Bakırköy, Turkey (Türkiye); Istanbul, Istanbul, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.