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Compares treatment options for Stroke
Official title Intensive Versus Conventional Blood Pressure Control Following Stroke Thrombectomy
ClinicalTrials.gov ID: NCT07350564
What this study is testing
- What it's testing
- This clinical trial aims to investigate the safety and efficacy of intensive blood pressure lowering after successful reperfusion with thrombectomy in patients with acute anterior circulation large artery occlusive stroke. The main questions it aims to answer are: What is the optimal blood pressure range after revascularization with thrombectomy in patients with cerebral embolism?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years
- To receive endovascular thrombectomy \<24 hours after the onset of symptoms
- Diagnosed with acute anterior circulation ischemic stroke
- National Institutes of Health Stroke Scale (NIHSS) score ≤ 30;
- Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6
You likely can't join if
- Pre-existing stroke disability defined by a modified Rankin score (mRS) \>2
- Unlikely to benefit from or tolerate endovascular thrombectomy, such as severe allergic reaction to contrast agents
- Failure to achieve mTICI ≥ 2b with endovascular intervention, or presence of in situ or proximal vascular stenosis
- Patients with contraindications for the use of antihypertensive medications, such as allergy to components
- Intracranial space-occupying lesions, including brain tumors and vascular malformations
- Patients with severe liver or renal dysfunction, or those receiving dialysis (severe liver dysfunction is defined as alanine aminotransferase [ALT]...
See the full eligibility criteria
- Age ≥ 18 years
- To receive endovascular thrombectomy \<24 hours after the onset of symptoms
- Diagnosed with acute anterior circulation ischemic stroke
- National Institutes of Health Stroke Scale (NIHSS) score ≤ 30;
- Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6
- Computed Tomography Angiography (CTA), Magnetic Resonance Angiography (MRA), or Digital Subtraction Angiography (DSA) confirming occlusion of the intracranial internal carotid artery or M1/M2 segment of the middle...
- Successful recanalization of the occluded vessel without in-situ or proximal stenosis (modified Treatment in Cerebral Infarction, mTICI ≥ 2b)
- Sustained elevated systolic blood pressure (≥140 mmHg for at least two consecutive measurements, separated by \>10 minutes) within 3 hours of reperfusion
- Written informed consent provided by the patient or their legal representative
- Pre-existing stroke disability defined by a modified Rankin score (mRS) \>2
- Unlikely to benefit from or tolerate endovascular thrombectomy, such as severe allergic reaction to contrast agents
- Failure to achieve mTICI ≥ 2b with endovascular intervention, or presence of in situ or proximal vascular stenosis
- Patients with contraindications for the use of antihypertensive medications, such as allergy to components
- Intracranial space-occupying lesions, including brain tumors and vascular malformations
- Patients with severe liver or renal dysfunction, or those receiving dialysis (severe liver dysfunction is defined as alanine aminotransferase [ALT] \> 3 times the upper limit of normal or aspartate aminotransferase...
- Serious illness with life expectancy of \<6 months
- Lactating women
- Participation in other treatment clinical trials within the past 3 months;
- Any other conditions that render patients unsuitable for participation in this study or unable to complete the study process, such as psychiatric disorders, cognitive or emotional impairments, or physical conditions...
The study team makes the final eligibility decision.
Where it's taking place
- Suzhou, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Suzhou, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.