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New treatment option for Pain Management
Official title Opioid-Sparing Joint Replacement
ClinicalTrials.gov ID: NCT07348627
What this study is testing
What is Oxycodone 5 mg?
Oxycodone 5 mg is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for pain management.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to evaluate whether an opioid-sparing postoperative pain regimen can reduce opioid consumption and maintain effective pain control in adults undergoing anterior total hip arthroplasty for osteoarthritis. The main questions it aims to answer are: Does an opioid-limited regimen result in lower postoperative opioid use compared with a standard opioid prescription?
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Diagnosis of hip osteoarthritis requiring primary arthroplasty
- Scheduled to undergo anterior total hip arthroplasty (THA)
- Able to comply with study procedures and follow-up visits
- Able to provide informed consent
You likely can't join if
- Concurrent significant injuries to other bones or organs
- Local infection at or near the surgical site
- Preoperative opioid use within 4 weeks prior to surgery
- History of severe heart disease (NYHA Class II or higher), renal failure, or liver dysfunction
- Chronic liver disease
- Neurological or psychiatric conditions that may influence pain perception
See the full eligibility criteria
- Diagnosis of hip osteoarthritis requiring primary arthroplasty
- Scheduled to undergo anterior total hip arthroplasty (THA)
- Able to comply with study procedures and follow-up visits
- Able to provide informed consent
- Concurrent significant injuries to other bones or organs
- Local infection at or near the surgical site
- Preoperative opioid use within 4 weeks prior to surgery
- History of severe heart disease (NYHA Class II or higher), renal failure, or liver dysfunction
- Chronic liver disease
- Neurological or psychiatric conditions that may influence pain perception
- Pregnancy
- History of alcohol or medication abuse
- Inability to take NSAIDs
- Use of postoperative DVT prophylaxis other than aspirin 81 mg twice daily
- Diabetes mellitus with HbA1c \> 8.0%
- Diagnosis of chronic pain syndrome or fibromyalgia
- Pain Catastrophizing Scale (PCS) score \> 29
- Any condition that, in the investigator's judgment, may interfere with adherence to study procedures or follow-up
The study team makes the final eligibility decision.
Where it's taking place
- Atlanta, Georgia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Atlanta, Georgia, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.