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New treatment option for Obesity
Official title AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
ClinicalTrials.gov ID: NCT07339423
What this study is testing
What is NNC0487-0111?
NNC0487-0111 is an investigational medicine, given as an once-weekly injection under the skin, being studied as a potential treatment for obesity.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Male or female (sex at birth).
- Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study...
- History of at least one self-reported unsuccessful dietary effort to lose body weight. Key
You likely can't join if
- HbA1c ≥ 6.5% (48 millimole per mole [mmol/mol]) as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based...
The study team makes the final eligibility decision.
Where it's taking place
- Miramar, Florida, United States
- Orlando, Florida, United States
- Conyers, Georgia, United States
- Skokie, Illinois, United States
- Indianapolis, Indiana, United States
- City of Saint Peters, Missouri, United States
- New York, New York, United States
- Chapel Hill, North Carolina, United States
- Greensboro, North Carolina, United States
- Wilmington, North Carolina, United States
- Philadelphia, Pennsylvania, United States
- Cumberland, Rhode Island, United States
- Charleston, South Carolina, United States
- North Charleston, South Carolina, United States
- Simpsonville, South Carolina, United States
- Amarillo, Texas, United States
- Dallas, Texas, United States
- Forney, Texas, United States
- Arlington, Virginia, United States
- Newport News, Virginia, United States
+ 52 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Miramar, Florida, United States; Orlando, Florida, United States; Conyers, Georgia, United States; Skokie, Illinois, United States; Indianapolis, Indiana, United States; City of Saint Peters, Missouri, United States and 66 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.