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New treatment option for Platelet Rich Plasma Injection
Official title The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis
ClinicalTrials.gov ID: NCT07339137
What this study is testing
- What it's testing
- The primary objective of this study is to evaluate and compare the effectiveness of ultrasound-guided combined intra-articular and peri-articular platelet-rich plasma (PRP) injections with intra-articular PRP injections alone in patients with chronic knee osteoarthritis (OA). The study specifically examines the effects of these treatment approaches on pain, physical function, activities of daily living, and structural parameters, including medial collateral ligament (MCL) thickness and distal femoral cartilage thickness.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 65
You may be able to join if
- Age between 40 and 65 years.
- Patients with significant medial knee pain who have not responded to conservative treatment for at least 3 months.
- Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria and with Kellgren-Lawrence grade 2 or 3...
- Intact cognitive function.
- Willingness to participate in the study and provide signed informed consent.
You likely can't join if
- History of previous knee trauma or surgery.
- Physical therapy, intra-articular steroid, or hyaluronic acid injections in the knee within the last 3 months.
- Active oncological diseases.
- Local infection, sepsis, wounds, or scars in the injection area.
- Systemic infections, hepatitis, or immunosuppression.
- Bleeding diathesis or irregular International Normalized Ratio (INR) due to oral warfarin use.
See the full eligibility criteria
- Age between 40 and 65 years.
- Patients with significant medial knee pain who have not responded to conservative treatment for at least 3 months.
- Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria and with Kellgren-Lawrence grade 2 or 3 radiographic osteoarthritis.
- Intact cognitive function.
- Willingness to participate in the study and provide signed informed consent.
- Visual Analog Scale (VAS) score of 4 or higher.
- History of previous knee trauma or surgery.
- Physical therapy, intra-articular steroid, or hyaluronic acid injections in the knee within the last 3 months.
- Active oncological diseases.
- Local infection, sepsis, wounds, or scars in the injection area.
- Systemic infections, hepatitis, or immunosuppression.
- Bleeding diathesis or irregular International Normalized Ratio (INR) due to oral warfarin use.
- Inflammatory arthropathies.
- Uncontrolled hypertension, uncontrolled diabetes mellitus, decompensated heart failure, coronary artery disease, or asthma.
- Suspected or confirmed pregnancy.
- Use of corticosteroids or opioids.
- Anemia.
- Body mass index (BMI) greater than 35.
- Allergy to citrate.
- Use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the last week that may affect platelet function analyzer-100 (PFA-100) activity.
- Physical examination findings suggestive of patellar retinaculum, meniscus, or cruciate ligament injury.
- General health impairment or lack of cooperation.
- Refusal to participate in the study.
The study team makes the final eligibility decision.
Where it's taking place
- Ankara, Çankaya, Turkey (Türkiye)
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ankara, Çankaya, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.