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New treatment option for Breast Cancer
Official title Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy
ClinicalTrials.gov ID: NCT07334626
What this study is testing
What is Calcium and Vitamin D Supplementation?
Calcium and Vitamin D Supplementation is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for breast cancer.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Breast cancer survivors receiving endocrine (hormonal) therapy (aromatase inhibitors) are at high risk for cancer treatment-induced bone loss and osteoporosis due to estrogen depletion.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 60, women only
You may be able to join if
- Female breast cancer survivors aged 40-60 years.
- Histologically confirmed stage I-III breast cancer.
- Currently receiving hormonal therapy (aromatase inhibitors) for at least 3 months.
- At risk of osteoporosis or with low bone mineral density (BMD) defined by T-score ≤ -1.0 at lumbar spine or hip.
- Medically cleared for exercise, specifically low-to-moderate intensity Pilates.
You likely can't join if
- Metastatic (stage IV) or recurrent breast cancer.
- History of osteoporotic fractures in the past 12 months.
- Severe cardiovascular, respiratory, or musculoskeletal conditions that contraindicate exercise.
- Uncontrolled hypertension, diabetes, or thyroid disorders.
- Current use of corticosteroids.
- Active bone metabolic disease other than osteoporosis (e.g., Paget's disease, osteomalacia).
See the full eligibility criteria
- Female breast cancer survivors aged 40-60 years.
- Histologically confirmed stage I-III breast cancer.
- Currently receiving hormonal therapy (aromatase inhibitors) for at least 3 months.
- At risk of osteoporosis or with low bone mineral density (BMD) defined by T-score ≤ -1.0 at lumbar spine or hip.
- Medically cleared for exercise, specifically low-to-moderate intensity Pilates.
- Able to attend supervised exercise sessions three times per week for 12 weeks.
- Willing and able to provide written informed consent.
- Metastatic (stage IV) or recurrent breast cancer.
- History of osteoporotic fractures in the past 12 months.
- Severe cardiovascular, respiratory, or musculoskeletal conditions that contraindicate exercise.
- Uncontrolled hypertension, diabetes, or thyroid disorders.
- Current use of corticosteroids.
- Active bone metabolic disease other than osteoporosis (e.g., Paget's disease, osteomalacia).
- Severe cognitive impairment or psychiatric illness preventing adherence to exercise or supplementation.
- Known allergy or intolerance to calcium or vitamin D supplementation.
- Participation in another clinical trial with structured exercise or bone-targeted intervention within the last 3 months.
The study team makes the final eligibility decision.
Where it's taking place
- Banhā, Benha, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 40 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Banhā, Benha, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.