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Tests treatment safety and results for Oral Leukoplakia
Official title Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment
ClinicalTrials.gov ID: NCT07331935
What this study is testing
- What it's testing
- Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older
You may be able to join if
- Clinically and histologically diagnosed with homogeneous oral leukoplakia not indicated for surgical excision .
- Lesions accessible for topical application.
- Willing to sign informed consent and comply with study instructions and return to follow up
You likely can't join if
- Moderate-to-severe dysplasia, carcinoma in situ, or invasive oral cancer.
- Presence of any visible oral lesions except for oral leukoplakia.
- Active periodontal diseases as this can confound salivary biomarkers.
- Significant systemic illness or immunosuppression.
- Patients who have taken systemic or topical antioxidant supplements within the last four weeks will be excluded to avoid confounding effects on...
- Pregnant and lactating women will be excluded due to hormonal changes that may alter oxidative stress and ethical considerations.
See the full eligibility criteria
- Clinically and histologically diagnosed with homogeneous oral leukoplakia not indicated for surgical excision .
- Lesions accessible for topical application.
- Willing to sign informed consent and comply with study instructions and return to follow up
- Moderate-to-severe dysplasia, carcinoma in situ, or invasive oral cancer.
- Presence of any visible oral lesions except for oral leukoplakia.
- Active periodontal diseases as this can confound salivary biomarkers.
- Significant systemic illness or immunosuppression.
- Patients who have taken systemic or topical antioxidant supplements within the last four weeks will be excluded to avoid confounding effects on salivary biomarkers.
- Pregnant and lactating women will be excluded due to hormonal changes that may alter oxidative stress and ethical considerations.
- Patients unwilling or unable to comply with study requirements.
The study team makes the final eligibility decision.
Where it's taking place
- Alexandria, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Alexandria, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.