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New treatment option for Peritoneal Mesothelioma
Official title PTC-Guided Therapy for Peritoneal Mesothelioma
ClinicalTrials.gov ID: NCT07330271
What this study is testing
What is PTC guided individualized treatment?
PTC guided individualized treatment is an investigational medicine, being studied as a potential treatment for peritoneal mesothelioma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Official Title: A Study of Key Parameters and Mechanisms in Personalized Diagnosis and Treatment Using Tumor Models Why is this study being done? This research study is for adults with a type of cancer called Malignant Peritoneal Mesothelioma (MPM).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Patients must meet ALL of the following criteria to be eligible for the study:
- Aged 18 years or older.
- Histopathologically confirmed diagnosis of epithelioid or biphasic malignant peritoneal mesothelioma (MPM).
- Scheduled to undergo cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) and subsequent adjuvant therapy.
- Availability of sufficient fresh tumor tissue sample obtained during surgery for Patient-derived tumor-like cell clusters (PTC) drug sensitivity...
You likely can't join if
- Patients who meet ANY of the following criteria will be excluded from the study:
- Presence of concurrent severe medical comorbidities that, in the investigator's judgment, preclude tolerance to the study treatment.
- Diagnosis of another active malignant tumor during the screening process, which may interfere with the study outcomes.
- Considered by the investigator to be unsuitable for participation in this study for any other reason (e.g., psychological, familial, or social...
- Unwillingness to accept the assigned treatment regimen or the required follow-up schedule.
See the full eligibility criteria
- Patients must meet ALL of the following criteria to be eligible for the study:
- Aged 18 years or older.
- Histopathologically confirmed diagnosis of epithelioid or biphasic malignant peritoneal mesothelioma (MPM).
- Scheduled to undergo cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) and subsequent adjuvant therapy.
- Availability of sufficient fresh tumor tissue sample obtained during surgery for Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.
- Karnofsky Performance Status (KPS) score \> 60.
- Adequate hematologic function:
- White blood cell count ≥ 3.5 × 10⁹/L
- Platelet count ≥ 80 × 10⁹/L
- Adequate hepatic function:
- Total bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) \< 2 × upper limit of normal (ULN)
- Adequate renal function:
- Serum creatinine \< 1.2 × ULN
- Adequate cardiac and pulmonary function to tolerate major surgery, as assessed by the investigator.
- Voluntarily agrees to participate by providing written informed consent and demonstrates good compliance.
- Patients who meet ANY of the following criteria will be excluded from the study:
- Presence of concurrent severe medical comorbidities that, in the investigator's judgment, preclude tolerance to the study treatment.
- Diagnosis of another active malignant tumor during the screening process, which may interfere with the study outcomes.
- Considered by the investigator to be unsuitable for participation in this study for any other reason (e.g., psychological, familial, or social factors).
- Unwillingness to accept the assigned treatment regimen or the required follow-up schedule.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.