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New treatment option for Herpes Simplex Keratitis
Official title Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
ClinicalTrials.gov ID: NCT07329686
What this study is testing
What is Intrastromal anti-VEGF injection and topical antiviral eye drops?
Intrastromal anti-VEGF injection and topical antiviral eye drops is an investigational medicine, given as an injectable medicine, being studied as a potential treatment for herpes simplex keratitis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action. It has been preliminarily applied in the treatment of fungal keratitis and neurotrophic corneal diseases.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Diagnosis: Patients who meet the diagnostic criteria for Herpes Simplex Virus (HSV) keratitis with neovascularization.
- Age: Adults aged 18 years or older.
- Previous Treatment: Patients who have not undergone other anti-VEGF treatments or corneal surgeries.
- Informed Consent: Patients who are capable of understanding and signing an informed consent form, agreeing to participate in the entire study process...
- Other: Additional criteria as deemed necessary by the investigator.
You likely can't join if
- Risk of Corneal Perforation: Patients at risk of corneal perforation.
- Severe Ocular Surface Dryness: Patients with severe dry eye syndrome.
- Systemic Diseases: Patients with systemic diseases that may affect the nervous or immune systems, such as diabetes, rheumatoid arthritis, autoimmune...
- Recent Use of Systemic Immunosuppressants: Patients who have recently used systemic immunosuppressive agents.
- Poor Compliance: Patients who are unable to follow up on time or adhere to the treatment plan.
- Pregnancy or Lactation: Pregnant or nursing women, as their physiological state may affect study outcomes.
See the full eligibility criteria
- Diagnosis: Patients who meet the diagnostic criteria for Herpes Simplex Virus (HSV) keratitis with neovascularization.
- Age: Adults aged 18 years or older.
- Previous Treatment: Patients who have not undergone other anti-VEGF treatments or corneal surgeries.
- Informed Consent: Patients who are capable of understanding and signing an informed consent form, agreeing to participate in the entire study process and to follow the study's follow-up schedule and treatment plan.
- Other: Additional criteria as deemed necessary by the investigator.
- Risk of Corneal Perforation: Patients at risk of corneal perforation.
- Severe Ocular Surface Dryness: Patients with severe dry eye syndrome.
- Systemic Diseases: Patients with systemic diseases that may affect the nervous or immune systems, such as diabetes, rheumatoid arthritis, autoimmune diseases, etc.
- Recent Use of Systemic Immunosuppressants: Patients who have recently used systemic immunosuppressive agents.
- Poor Compliance: Patients who are unable to follow up on time or adhere to the treatment plan.
- Pregnancy or Lactation: Pregnant or nursing women, as their physiological state may affect study outcomes.
- Allergy History: Patients with a history of allergies to the study medication or related components.
- Other Reasons: Patients deemed by the investigator to have other reasons making them unsuitable for participation in the trial.
The study team makes the final eligibility decision.
Where it's taking place
- Hangzhou, Zhejiang, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hangzhou, Zhejiang, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.