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New treatment option for Experimental Pain in Healthy Human Subjects
Official title Tonic Pain and Transauricular Vagal Nerve Stimulation
ClinicalTrials.gov ID: NCT07325058
What this study is testing
- What it's testing
- This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception. Primary outcomes include pain intensity.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 16 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Healthy
- Speak and understand English
- 18-60 years old.
You likely can't join if
- Pregnant and/or breastfeeding
- Regular use of cannabis, opioids or other drugs
- Current or previous neurologic, musculoskeletal, mental, or other illnesses (e.g., brain or spinal cord injuries, degenerative neurological...
- Current regular (once or more a week) use of analgesic medication or other medication which may affect the trial (including paracetamol and NSAIDs)
- Recent history of acute pain particularly in the lower limbs
- Abnormally disrupted sleep in 24 hours preceding experiment
See the full eligibility criteria
- Healthy
- Speak and understand English
- 18-60 years old.
- Pregnant and/or breastfeeding
- Regular use of cannabis, opioids or other drugs
- Current or previous neurologic, musculoskeletal, mental, or other illnesses (e.g., brain or spinal cord injuries, degenerative neurological disorders, major depression, cardiovascular disease, chronic lung disease, etc.)
- Current regular (once or more a week) use of analgesic medication or other medication which may affect the trial (including paracetamol and NSAIDs)
- Recent history of acute pain particularly in the lower limbs
- Abnormally disrupted sleep in 24 hours preceding experiment
- Contraindications to electric stimulation application (history of epilepsy, metal implants in head or jaw, etc.)
- Lack of ability to cooperate
- Contraindications for capsaicin including an intolerance chili consumption and burns or wounds to the application site.
The study team makes the final eligibility decision.
Where it's taking place
- Aalborg, Denmark
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 16 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aalborg, Denmark. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.