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Tests treatment safety and results for Arthritis, Psoriatic
Official title A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
ClinicalTrials.gov ID: NCT07321873
What this study is testing
What is JNJ-88545223?
JNJ-88545223 is an investigational medicine, being studied as a potential treatment for arthritis, psoriatic.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification...
- Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (Week 0/Day 1) based on the...
- Have \>= 1 of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules...
- Have active plaque psoriasis with at least one psoriatic plaque of \>= 2 centimeter (cm) diameter or nail changes consistent with psoriasis
- A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (Beta-hCG) at screening and a negative...
You likely can't join if
- Has a nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular)
- Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal...
- Has suspected or known allergies, hypersensitivity, or intolerance to JNJ-88545223 or excipients used in the investigational medicinal product (IMP)...
- Has fibromyalgia or osteoarthritis symptoms that, in the opinion of the investigator, would have potential to interfere with how well it works...
- Currently has a malignancy or has a history of malignancy within 5 years prior to screening
The study team makes the final eligibility decision.
Where it's taking place
- Searcy, Arkansas, United States
- Huntington Beach, California, United States
- San Diego, California, United States
- Cutler Bay, Florida, United States
- Palmetto Bay, Florida, United States
- Plantation, Florida, United States
- Tampa, Florida, United States
- Winter Park, Florida, United States
- Marietta, Georgia, United States
- Willowbrook, Illinois, United States
- Evansville, Indiana, United States
- Albuquerque, New Mexico, United States
- Charlotte, North Carolina, United States
- Middleburg Heights, Ohio, United States
- Philadelphia, Pennsylvania, United States
- Allen, Texas, United States
- Beijing, China
- Changsha, China
- Changzhou, China
- Chengdu, China
+ 40 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Searcy, Arkansas, United States; Huntington Beach, California, United States; San Diego, California, United States; Cutler Bay, Florida, United States; Palmetto Bay, Florida, United States; Plantation, Florida, United States and 54 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.