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Compares treatment options for Severe Knee Osteoarthritis
Official title Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis
ClinicalTrials.gov ID: NCT07316933
What this study is testing
- What it's testing
- This study aims to evaluate the acute effects of blood flow restriction (BFR) training on hypoalgesia and neuromuscular responses in patients with severe gonarthrosis by comparing the application of pressure with a dynamic versus a fixed configuration. There will be six different training conditions with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure; 3) 50% RM and 50% BFR with dynamic pressure; 4) 50% RM and 50% BFR with fixed pressure; 5) 30% RM and 80% BFR with dynamic pressure; 6) 30% RM and 80% BFR with fixed pressure.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 85
You may be able to join if
- Age between 50 and 85 years
- Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines.
- On the waiting list for unilateral total knee replacement (TKR) surgery
You likely can't join if
- Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog scale (VAS) during daily activities.
- Previous hip or knee replacement surgery and osteotomy within the last year.
- Autoimmune arthritis
- Medical conditions that contraindicate exercise.
- Participation in exercise programs (\>2 days/week with training at intensities of 10-15 1RM) in the previous six months.
- History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study.
See the full eligibility criteria
- Age between 50 and 85 years
- Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines.
- On the waiting list for unilateral total knee replacement (TKR) surgery
- Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog scale (VAS) during daily activities.
- Previous hip or knee replacement surgery and osteotomy within the last year.
- Autoimmune arthritis
- Medical conditions that contraindicate exercise.
- Participation in exercise programs (\>2 days/week with training at intensities of 10-15 1RM) in the previous six months.
- History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study.
- Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled...
- Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema).
- Inability to communicate normally or with impaired communication skills.
The study team makes the final eligibility decision.
Where it's taking place
- Valencia, Valencia, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Valencia, Valencia, Spain. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.