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New treatment option for Periodontal Disease (PD)
Official title PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
ClinicalTrials.gov ID: NCT07311512
What this study is testing
- What it's testing
- Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 75
You may be able to join if
- Participants must have a minimum of 2 natural teeth in each sextant (at least 12 teeth overall).
- Individuals with clinically diagnosed gingivitis and/or early periodontitis (stage 1 and 2)
- Must not have undergone periodontal maintenance therapy (PMPR) within the last 6 months.
- Must not currently be wearing orthodontic appliances, due to their effect on oral microbiota and plaque composition.
- Must not be using removable orthodontic appliances, as they increase plaque accumulation.
You likely can't join if
- Individuals under regular medication within one month of the study start date for any medical condition (such as hypertension and/or diabetes)
- Pregnant or breastfeeding individuals.
- Individuals requiring an interpreter or who are non-English speakers.
- Individuals unable to provide written informed consent.
- Individuals participating in another ongoing clinical study (other than observational studies) within 3 months prior to or during this study.
- Individuals who have used mouthwash or tongue scrapers in the last 6 weeks.
See the full eligibility criteria
- Participants must have a minimum of 2 natural teeth in each sextant (at least 12 teeth overall).
- Individuals with clinically diagnosed gingivitis and/or early periodontitis (stage 1 and 2)
- Must not have undergone periodontal maintenance therapy (PMPR) within the last 6 months.
- Must not currently be wearing orthodontic appliances, due to their effect on oral microbiota and plaque composition.
- Must not be using removable orthodontic appliances, as they increase plaque accumulation.
- Must not have taken any antibiotic treatments within the last 3 months.
- Must be able to provide written informed consent.
- Individuals with dental erosion or caries will still be included but matched during the baseline visit.
- Individuals under regular medication within one month of the study start date for any medical condition (such as hypertension and/or diabetes)
- Pregnant or breastfeeding individuals.
- Individuals requiring an interpreter or who are non-English speakers.
- Individuals unable to provide written informed consent.
- Individuals participating in another ongoing clinical study (other than observational studies) within 3 months prior to or during this study.
- Individuals who have used mouthwash or tongue scrapers in the last 6 weeks.
- Individuals who consume 20 or more cigarettes per day.
- Individuals who consume more than 5 alcoholic drinks per day.
The study team makes the final eligibility decision.
Where it's taking place
- Portsmouth, Hampshire, United Kingdom
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Portsmouth, Hampshire, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.