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Tests treatment safety and results for Atherosclerosis Cardiovascular Disease
Official title Efficacy, Safety, and PopPK Profile of ABP-745 in Patients With Atherosclerosis
ClinicalTrials.gov ID: NCT07303777
What this study is testing
What is ABP-745 Dose A?
ABP-745 Dose A is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for atherosclerosis cardiovascular disease.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a multicenter, randomized, double-blind, placebo parallel controlled study to evaluate the preliminary efficacy, safety, and PopPK profile of ABP-745 in patients with ASCVD. Efficacy of ABP-745 in reducing atherosclerotic plaque compared with placebo will be evaluated in participants with ASCVD.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Unless otherwise specified, people must meet all of the following criteria at screening:
- Diagnosed with coronary at herosclerosis, and coronary angiography.
- Male or female at 18-75 years of age (inclusive).
- Weight ≥40 kg.
- Currently using any oral lipid-lowering therapy.
You likely can't join if
- Unless otherwise specified, people are excluded from the study if any of the following criteria is met:
- History of stroke within the past 6 months.
- Uncontrolled arrhythmia within 3 months prior to screening.
- Evidence of any active or suspected cancer within 3 years prior to the screening.
- Having undergone any major surgery within 3 months prior to the screening or planning to undergo any major surgery during the study.
- Presence or suspicion of ongoing of any serious infection.
See the full eligibility criteria
- Unless otherwise specified, people must meet all of the following criteria at screening:
- Diagnosed with coronary at herosclerosis, and coronary angiography.
- Male or female at 18-75 years of age (inclusive).
- Weight ≥40 kg.
- Currently using any oral lipid-lowering therapy.
- Able to understand and willing to sign an ICF and comply with study requirements.
- A woman or man of childbearing potential agreeing to use medically approved contraceptive methods from the screening until 3 months after the last study dose.
- Unless otherwise specified, people are excluded from the study if any of the following criteria is met:
- History of stroke within the past 6 months.
- Uncontrolled arrhythmia within 3 months prior to screening.
- Evidence of any active or suspected cancer within 3 years prior to the screening.
- Having undergone any major surgery within 3 months prior to the screening or planning to undergo any major surgery during the study.
- Presence or suspicion of ongoing of any serious infection.
- Human immunodeficiency virus (HIV) infection.
The study team makes the final eligibility decision.
Where it's taking place
- Beverly Hills, California, United States
- San Diego, California, United States
- Torrance, California, United States
- St Louis, Missouri, United States
- Newcastle, New South Wales, Australia
- Morayfield, Queensland, Australia
- Brisbane, Australia
- Wahroonga, Australia
- Beijing, China
- Dalian, China
- Guangzhou, China
- Hangzhou, China
- Jinan, China
- Nanjing, China
- Shanghai, China
- Suzhou, China
- Tianjin, China
- Wuhan, China
- Wuxi, China
- Xi'an, China
+ 1 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beverly Hills, California, United States; San Diego, California, United States; Torrance, California, United States; St Louis, Missouri, United States; Newcastle, New South Wales, Australia; Morayfield, Queensland, Australia and 15 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.