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New treatment option for Sleep Deprivation
Official title Circadian Rhythms and Time Perception in Healthy Adults During Constant Wakefulness
ClinicalTrials.gov ID: NCT07294781
What this study is testing
- What it's testing
- This study examines how the internal body clock (circadian rhythms) influences the way healthy adults experience time, think, and feel when they stay awake for an extended period. Participants will spend about 36 hours in a controlled sleep laboratory while remaining awake the entire time.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 23 to 45. Healthy volunteers may be eligible.
You may be able to join if
- Age 23 to 45 years.
- Able and willing to provide written informed consent.
- Fluent in Danish and able to understand study procedures and instructions.
- Generally healthy, as assessed by medical history, screening questionnaires, and basic clinical measures (e.g., blood pressure, heart rate).
- Self-reported regular sleep-wake schedule for at least 4 weeks prior to the laboratory visit (typically 6.5-9 hours of sleep per night, with usual...
You likely can't join if
- Any known or suspected major sleep disorder (e.g., insomnia disorder, obstructive sleep apnoea, restless legs syndrome, narcolepsy), based on...
- Current or past major psychiatric or neurological disorders (e.g., major depressive disorder, bipolar disorder, psychotic disorders, epilepsy)...
- Chronic medical conditions that could be worsened by prolonged wakefulness or that might confound outcome measures, such as significant...
- Regular use of medications or supplements that may affect sleep, circadian rhythms, melatonin secretion, alertness, or mood (e.g., hypnotics...
- High habitual caffeine intake (for example, \>400 mg/day) or nicotine dependence if the participant is unable or unwilling to abstain for the...
- Current harmful alcohol use or substance use disorder, or frequent use of recreational drugs.
See the full eligibility criteria
- Age 23 to 45 years.
- Able and willing to provide written informed consent.
- Fluent in Danish and able to understand study procedures and instructions.
- Generally healthy, as assessed by medical history, screening questionnaires, and basic clinical measures (e.g., blood pressure, heart rate).
- Self-reported regular sleep-wake schedule for at least 4 weeks prior to the laboratory visit (typically 6.5-9 hours of sleep per night, with usual sleep period between approximately 22:00-01:00 and 06:00-09:00).
- Body mass index (BMI) within a non-extreme range (for example, approximately 18.5-30 kg/m²), if required by the study physician.
- No regular night work or rotating shift work during the 3 months before participation.
- No travel across more than 2 time zones in the 2 months before the constant-routine session.
- Willing to abstain from caffeine, nicotine, alcohol, and recreational drugs for the specified washout periods before and during the 36-hour constant-routine session.
- For participants who can become pregnant: negative pregnancy test at screening/arrival and agreement to use reliable contraception for the duration of participation.
- Any known or suspected major sleep disorder (e.g., insomnia disorder, obstructive sleep apnoea, restless legs syndrome, narcolepsy), based on self-report or prior diagnosis.
- Current or past major psychiatric or neurological disorders (e.g., major depressive disorder, bipolar disorder, psychotic disorders, epilepsy), unless considered mild and stable and explicitly approved by the study...
- Chronic medical conditions that could be worsened by prolonged wakefulness or that might confound outcome measures, such as significant cardiovascular disease, uncontrolled hypertension, diabetes mellitus, severe...
- Regular use of medications or supplements that may affect sleep, circadian rhythms, melatonin secretion, alertness, or mood (e.g., hypnotics, sedative-hypnotics, melatonin, stimulants, certain antidepressants or...
- High habitual caffeine intake (for example, \>400 mg/day) or nicotine dependence if the participant is unable or unwilling to abstain for the required washout periods.
- Current harmful alcohol use or substance use disorder, or frequent use of recreational drugs.
- Pregnancy or breastfeeding.
- Previous severe adverse reaction to sleep deprivation, extended wakefulness, or similar laboratory protocols.
- Claustrophobia or inability to tolerate prolonged stays in a controlled laboratory environment.
- Any condition or circumstance that, in the judgement of the investigators, would make participation unsafe, interfere with the 36-hour wakefulness protocol, or compromise data quality (e.g., inability to remain awake...
The study team makes the final eligibility decision.
Where it's taking place
- Aarhus, Denmark
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 23 years to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Aarhus, Denmark. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.