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New treatment option for Anesthesia
Official title Remimazolam NeuroImaging
ClinicalTrials.gov ID: NCT07290205
What this study is testing
What is Remimazolam?
Remimazolam is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for anesthesia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a single-arm functional MRI study that will determine the effects of remimazolam on cognition and brain activity and connectivity at rest, during noxious stimulation, and during a memory encoding task
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 59. Healthy volunteers may be eligible.
You may be able to join if
- Adults 18-59 years of age, who:
- have none of the specific
You likely can't join if
- have a valid email address and valid phone number throughout the study
- free from any non-MRI compatible implants Exclusion Criteria:
- are pregnant or attempting to conceive
- body mass index (BMI) \> 35
- significant memory impairment or hearing loss
- sleep apnea
See the full eligibility criteria
- Adults 18-59 years of age, who:
- have none of the specific
- have a valid email address and valid phone number throughout the study
- free from any non-MRI compatible implants Exclusion Criteria:
- are pregnant or attempting to conceive
- body mass index (BMI) \> 35
- significant memory impairment or hearing loss
- sleep apnea
- chronic pain or frequently taking pain medication (including tramadol)
- chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol)
- neurologic disease, including seizures and tremor
- psychiatric diagnoses, including anxiety, depression, panic, or PTSD
- a history of any of these medical conditions: abnormal heartbeats (cardiac conduction abnormality or arrhythmia), liver or kidney disease, or significant lung disease
- severe claustrophobia or MRI intolerance
- have metal implants or non-removable metal piercings
- having a history of adverse reaction to midazolam (Versed), lorazepam (Ativan) or another benzodiazepine class medication
- are allergic to dextran
- daily alcohol or heavy alcohol use; history of alcohol abuse
- current daily smoker
- regular or recent marijuana use (including prescribed/medical marijuana)
- illicit drug use, i.e., street drugs
- regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 59 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.